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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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1437-4331
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Volume 58, Issue 2

Issues

Serum or plasma? An old question looking for new answers

Mario PlebaniORCID iD: https://orcid.org/0000-0002-0270-1711 / Giuseppe Banfi
  • Direttore Scientifico, IRCCS Istituto Ortopedico Galeazzi, Università Vita e Salute San Raffaele, Milan, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sergio Bernardini / Francesco Bondanini
  • Unità Operativa Complessa Patologia Clinica Presidio, Ospedaliero Sant’Eugenio/CTO ASL Roma 2, Rome, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Laura Conti / Romolo Dorizzi / Fulvio Enrico Ferrara
  • Direttore Servizio Integrato di Medicina di Laboratorio e Anatomia Patologica, Centro Diagnostico Italiano Spa, Milan, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Rita Mancini / Tommaso Trenti
  • Dipartimento di Medicina di Laboratorio e Anatomia Patologica Azienda Ospedaliera Universitaria e USL di Modena, Modena, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2019-09-17 | DOI: https://doi.org/10.1515/cclm-2019-0719

Abstract

Serum or plasma? An old question looking for new answers. There is a continual debate on what type of sample a clinical laboratory should use. While serum is still considered the gold standard and remains the required sample for some assays, laboratories must consider turn-around time, which is an important metric for laboratory performance and, more importantly, plays a critical role in patient care. In addition, a body of evidence emphasise the choice of plasma in order to prevent modifications of some analytes due to the coagulation process and related interferences. Advantages and disadvantages of serum and plasma are discussed on the basis of current literature and evidence. In addition, data are provided on the current utilisation of the samples (serum or plasma) in Italy and in other countries. Finally, a rationale for a possible switch from serum to plasma is provided.

Keywords: anticoagulants; clinical laboratory; plasma; sample of choice; serum; whole blood

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About the article

Corresponding author: Prof. Mario Plebani, Dipartimento Strutturale Medicina di Laboratorio, Azienda Ospedale Università di Padova, Via Giustiniani, 2, 35128 Padova, Italy, Phone: 0498212792


Received: 2019-07-15

Accepted: 2019-08-22

Published Online: 2019-09-17

Published in Print: 2020-01-28


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Potential conflicts of interest: This document was produced with the non-conditional contribution of Becton Dickinson Italia SpA.

Competing interests: The funding organisation(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 58, Issue 2, Pages 178–187, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2019-0719.

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