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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 56, Issue 4


Evaluation of long-term stability of cannabinoids in standardized preparations of cannabis flowering tops and cannabis oil by ultra-high-performance liquid chromatography tandem mass spectrometry

Roberta Pacifici
  • Corresponding author
  • National Centre on Addiction and Doping, Istituto Superiore di Sanità, V.le Regina Elena 299, 00161, Rome, Italy, Phone: +390649906544, Fax: +390649902016
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Emilia Marchei / Francesco Salvatore
  • Agenzia Industrie e Difesa, Stabilimento Chimico Farmaceutico Militare; (Military Pharmaceutical Chemical Works of Florence), Florence, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Luca Guandalini
  • Agenzia Industrie e Difesa, Stabilimento Chimico Farmaceutico Militare; (Military Pharmaceutical Chemical Works of Florence), Florence, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Francesco Paolo Busardò
  • Unit of Forensic Toxicology (UoFT), Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Simona Pichini
Published Online: 2017-11-27 | DOI: https://doi.org/10.1515/cclm-2017-0758


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    Decreto 9 novembre 2015: Funzioni di Organismo statale per la cannabis previsto dagli articoli 23 e 28 della convenzione unica sugli stupefacenti del 1961, come modificata nel 1972. Available at: http://www.gazzettaufficiale.it/eli/id/2015/11/30/15A08888/sg;jsessionid=p1rnwNujUKlqQ5azhAQ95A__.ntc-as3-guri2a. Accessed: 24 Aug 2017.

  • 2.

    Pacifici R, Marchei E, Salvatore F, Guandalini L, Busardò FP, Pichini S. Evaluation of cannabinoids concentration and stability in standardized preparations of cannabis tea and cannabis oil by ultra-high performance liquid chromatography tandem mass spectrometry. Clin Chem Lab Med 2017;55:1555–63. [Epub ahead of print].PubMedWeb of ScienceGoogle Scholar

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    Rock EM, Limebeer CL, Parker LA. Effect of combined doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea using rat (Sprague-Dawley) models of conditioned gaping. Psychopharmacology 2015;232:4445–4.Web of ScienceCrossrefPubMedGoogle Scholar

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    Brierley DI, Samuels J, Duncan M, Whalley BJ, Williams CM. Neuromotor tolerability and behavioural characterisation of cannabidiolic acid, a phytocannabinoid with therapeutic potential for anticipatory nausea. Psychopharmacology 2016;233:243–54.Web of SciencePubMedCrossrefGoogle Scholar

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About the article

Received: 2017-08-25

Accepted: 2017-09-21

Published Online: 2017-11-27

Published in Print: 2018-03-28

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: Funded by the project: “Implementazione dei Sistemi di Sorveglianza sul disturbo da gioco d’azzardo e sull’uso medico della cannabis sul territorio Nazionale” by the Ministry of Health.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 56, Issue 4, Pages 94–96, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2017-0758.

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