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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
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Volume 57, Issue 8

Issues

Hb Hunan and Hb Hengyang: Two unexpected discoveries during HbA1c measurements

Anping Xu
  • Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, P.R. China
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/ Jie Lei
  • Department of Laboratory Medicine, Maternity and Child Healthcare Hospital of Nanshan District, Shenzhen, P.R. China
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/ Jie Li
  • Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, P.R. China
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/ Weidong Chen
  • Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, P.R. China
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/ Yu Zhou
  • Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, P.R. China
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/ Ruoyang Zheng
  • Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, P.R. China
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/ Xiaofeng Li
  • Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, P.R. China
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/ Ling Ji
  • Corresponding author
  • Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, P.R. China, Phone: +86-0755-83923333-2299
  • Email
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Published Online: 2019-02-02 | DOI: https://doi.org/10.1515/cclm-2018-1029

References

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    UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS33). Lancet 1998;352:837–53.Google Scholar

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    Bots M, Stroobants AK, Delzenne B, Soeters MR, de Vries JE, Weykamp CW, et al. Two novel haemoglobin variants that affect haemoglobin A1c measurement by ion-exchange chromatography. Clin Chem Lab Med 2015;53:1465–71.PubMedGoogle Scholar

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    Benítez IC, Lameiro PC, Ropero P, De la Osa JJ, Fernández FG, Ortiz AM. Hemoglobin Valme HBB:c.124T>G:A new hemoglobin variant with diminished oxygen affinity causes interference in hemoglobin A1c measurement in an automated ion-exchange HPLC method. Clin Chem Lab Med 2015;53:e211–3.Google Scholar

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    Molchanova TP, Pobedimskaya DD, Huisman TH. The differences in quantities of alpha 2- and alpha 1-globin gene variants in heterozygotes. Br J Haematol 1994;88:300–6.PubMedCrossrefGoogle Scholar

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    Cabannes R, Renaud R, Mauran A, Pennors H, Charlesworth D, Price BG, et al. Two fast hemoglobins in Ivory-Coast: Hb K Woolwich and a new hemoglobin Hb J Abidjan (alpha-51 Gly-Asp). Nouv Rev Fr Hematol 1972;12:289–300.Google Scholar

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    Lacan P, Moreau M, Becchi M, Zanella-Cleon I, Aubry M, Louis JJ, et al. Two new hemoglobin variants: Hb Brem-sur-Mer [beta9(A6)Ser–>Tyr] and Hb Passy [alpha81(F2)Ser–>Pro (alpha2)]. Hemoglobin 2005;29:69–75.CrossrefPubMedGoogle Scholar

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    Rohlfing C, Connolly S, Hanson S, Higgins T, Little RR. Validation of the use of trinity biotech ultra2 as a comparative method for hemoglobin A1c measurements in the presence of HbE and HbD-Punjab traits. Clin Chem 2017;63:608–10.CrossrefPubMedGoogle Scholar

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    Ji L, Yu J, Zhou Y, Xia Y, Xu A, Li W, et al. Erroneous HbA1c measurements in the presence of β-thalassemia and common Chinese hemoglobin variants. Clin Chem Lab Med 2015;53:1451–8.PubMedGoogle Scholar

About the article

Received: 2018-09-19

Accepted: 2018-12-20

Published Online: 2019-02-02

Published in Print: 2019-07-26


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), Volume 57, Issue 8, Pages e196–e198, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2018-1029.

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