Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
See all formats and pricing
More options …
Ahead of print

Issues

Increased C-reactive protein values in the absence of inflammation: monoclonal immunoglobulin interference in immunonephelometry

Frederick Verbeke / Stijn Lambrecht / Elke Lecocq / Jean-Jacques Parez / Joris Delanghe
  • Corresponding author
  • Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium, Phone: +329 332 29 56, Fax: +329 332 49 85
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2019-06-11 | DOI: https://doi.org/10.1515/cclm-2019-0398

References

  • 1.

    Ledue TB, Weiner DL, Sipe JD, Poulin SE, Collins MF, Rifai N. Analytical evaluation of particle-enhanced immunonephelometric assays for C-reactive protein, serum amyloid A and mannose-binding protein in human serum. Ann Clin Biochem 1998;35:745–53.CrossrefPubMedGoogle Scholar

  • 2.

    Volanakis JE, Clements WL, Schrohenloher RE. C-reactive protein. Purification by affinity chromatography and physicochemical characterization. J Immunol Meth 1978;23:285–95.CrossrefGoogle Scholar

  • 3.

    Brada D, Roth J. ‘Golden blot’. Detection of polyclonal and monoclonal antibodies bound to antigens on nitrocellulose by protein A-gold complexes. Anal Biochem 1984;142:79–83.CrossrefGoogle Scholar

  • 4.

    Roberts WL, Sedrick R, Moulton L, Spencer A, Rifai N. Evaluation of four automated high-sensitivity C-reactive protein methods: implications for clinical and epidemiological applications. Clin Chem 2000;46:461–8.PubMedGoogle Scholar

  • 5.

    Highton J, Hessian P. A solid-phase enzyme immunoassay for C-reactive protein: clinical value and the effect of rheumatoid factor. J Immunol Methods 1984;68:185–92.CrossrefPubMedGoogle Scholar

  • 6.

    Berth M, Delanghe J. Protein precipitation as a possible important pitfall in the clinical chemistry analysis of blood samples containing monoclonal immunoglobulins: 2 case reports and a review of the literature. Acta Clin Belgica 2004;59:263–73.CrossrefGoogle Scholar

  • 7.

    Yu A, Pira U. False increase in serum C-reactive protein caused by monoclonal IgM-λ: a case report. Clin Chem Lab Med 2001;39:983–7.PubMedGoogle Scholar

  • 8.

    Rajkumar SV, Kyle RA, Therneau TM, Melton III LJ, Bradwell AR, Clark RJ, et al. Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance. Blood 2005;106:812–7.PubMedCrossrefGoogle Scholar

  • 9.

    Kyle RA, Benson J, Larson D, Therneau T, Dispenzieri A, Melton III LJ, et al. IgM monoclonal gammopathy of undetermined significance and smoldering Waldenström’s macroglobulinemia. Clin Lymphoma Myeloma 2009;9:17–8.CrossrefPubMedGoogle Scholar

  • 10.

    Hatzimichael EC, Christou L, Bai M, Kolios G, Kefala L, BourantasKL. Serum levels of IL-6 and its soluble receptor (sIL-6R) in Waldenström’s macroglobulinemia. Eur J Haematol 2001;66:1–6.PubMedCrossrefGoogle Scholar

About the article

Received: 2019-04-15

Accepted: 2019-05-11

Published Online: 2019-06-11


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: Immunonephelometry monoclonal antibody was provided free of charge by Siemens. Siemens played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), 20190398, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2019-0398.

Export Citation

©2019 Walter de Gruyter GmbH, Berlin/Boston.Get Permission

Comments (0)

Please log in or register to comment.
Log in