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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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1437-4331
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Methods for quick, accurate and cost-effective determination of the type 1 diabetes genetic risk score (T1D-GRS)

Jonathan M. Locke
  • Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Devon, UK
  • Other articles by this author:
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/ Mark J. Latten / Renu Y. Datta / Andrew R. Wood
  • Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Devon, UK
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Martin A. Crockard / John V. Lamont / Michael N. Weedon
  • Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Devon, UK
  • Other articles by this author:
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/ Richard A. Oram
  • Corresponding author
  • Institute of Biomedical and Clinical Science, University of Exeter Medical School, Level 3, RILD Building, Barrack Road, Exeter, Devon, EX2 5DW, UK, Phone: 01392 408538, Fax: 01392 408388
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2019-10-30 | DOI: https://doi.org/10.1515/cclm-2019-0787

References

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    Oram RA, Patel K, Hill A, Shields B, McDonald TJ, Jones A, et al. A type 1 diabetes genetic risk score can aid discrimination between type 1 and type 2 diabetes in young adults. Diabetes Care 2016;39:337–44.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 2.

    Redondo MJ, Geyer S, Steck AK, Sharp S, Wentworth JM, Weedon MN, et al. A type 1 diabetes genetic risk score predicts progression of islet autoimmunity and development of type 1 diabetes in individuals at risk. Diabetes Care 2018;41:1887–94.Web of ScienceCrossrefPubMedGoogle Scholar

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    Semagn K, Babu R, Hearne S, Olsen M. Single nucleotide polymorphism genotyping using kompetitive allele specific PCR (KASP): overview of the technology and its application in crop improvement. Mol Breeding 2013;33:1–14.Web of ScienceGoogle Scholar

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    Martin R, Latten M, Hart P, Murray H, Bailie DA, Crockard M, et al. Genetic diagnosis of familial hypercholesterolaemia using a rapid biochip array assay for 40 common ldlr, apob and pcsk9 mutations. Atherosclerosis 2016;254:8–13.Web of SciencePubMedCrossrefGoogle Scholar

  • 5.

    Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, Fennell T, et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature 2016;536:285–91.CrossrefPubMedWeb of ScienceGoogle Scholar

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    Nanayakkara IA, Cao W, White IM. Simplifying nucleic acid amplification from whole blood with direct polymerase chain reaction on chitosan microparticles. Anal Chem 2017;89:3773–9.CrossrefPubMedWeb of ScienceGoogle Scholar

About the article

Received: 2019-07-30

Accepted: 2019-10-04

Published Online: 2019-10-30


Funding Source: Wellcome Trust Institutional Support

Award identifier / Grant number: WT097835MF

Funding Source: Diabetes UK

Award identifier / Grant number: 16/0005529

This work has been funded by a Medical Research Council Confidence in Concept grant awarded to R.A.O in collaboration with Randox Laboratories Ltd. M.N.W. is supported by the Wellcome Trust Institutional Support Fund, Funder Id: http://dx.doi.org/10.13039/100004440 (WT097835MF). R.A.O. is supported by a Diabetes UK Harry Keen Fellowship, Funder Id: http://dx.doi.org/10.13039/501100000361 (16/0005529).


Author contributions: All authors confirmed they have contributed to the intellectual content of this paper and have met the following four requirements: (a) significant contributions to the conception and design, acquisition of data, or analysis and interpretation of data; (b) drafting or revising the article for intellectual content; (c) final approval of the published article; and (d) agreement to be accountable for all aspects of the article thus ensuring that questions related to the accuracy or integrity of any part of the article are appropriately investigated and resolved. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM), 20190787, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm-2019-0787.

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