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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.

CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

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Spatial resolution of electrical source localization depends on inter-electrode spacing and signal-to-noise ratio

Martin Nguyen
  • Corresponding author
  • Technische Hochschule Mittelhessen, Dept. Life Science Engineering, Wiesenstraße 14, 35390 Giessen, Germany
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/ Thomas Schanze
Published Online: 2017-09-07 | DOI: https://doi.org/10.1515/cdbme-2017-0019


Extracellular recordings of electrical neuronal sources with non-planar multichannel microelectrodes promise a high spatio-temporal resolution. We have developed signal-based algorithms, simulations and models to inversely estimate neuronal source positions and electrical properties by using multi-sensor recorded extracellular action potentials (EAP). Here, we analyse the dependence of electrode configurations on the position estimation by simulations. Estimations were simulated for various inter-electrode spacings, electrode-source distances and signal-to-noise ratios. The results show that inverse estimation depends on the electrode size or rather on the inter-electrode spacing. We find, as a rule, the larger the spacing, the larger the eligible source location area, but estimation quality of sources which are in the proximity of an electrode contact decreases. In addition, noise worsen the estimation and decreases the assessable distance between source and electrode. Thus, multichannel micro-electrodes should be selected towards signal and spatial sensitivity requirements.

Keywords: Neuron; Electrical source; Localization; Microelectrode; Inverse problem; Estimation

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Published Online: 2017-09-07

Citation Information: Current Directions in Biomedical Engineering, Volume 3, Issue 2, Pages 87–90, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2017-0019.

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©2017 Martin Nguyen et al., published by De Gruyter, Berlin/Boston. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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