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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.


CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

Open Access
Online
ISSN
2364-5504
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Imaging in hearing using radiotracers

Georg Berding
  • Corresponding author
  • Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany
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/ Thomas Lenarz
Published Online: 2017-09-07 | DOI: https://doi.org/10.1515/cdbme-2017-0039

Abstract

Radiotracers offer unique options for brain imaging of functional and molecular processes related to hearing. Such imaging can be applied in a broad spectrum of situations from preclinical research to clinical patient care. Functional imaging to assess activation in brain regions and networks involved in auditory processing uses markers of blood flow or energy-metabolism in well-defined conditions with and without auditory stimulation. Molecular markers can be used in hearing research for example to study changes in inhibitory neurotransmission systems related to hearing loss. For imaging either positron emission tomography (PET) or single-photon emission computed tomography (SPECT) are employed. Data analysis can encompasses voxel-wise statistical analysis of activation and calculation of quantitative parameters like receptor binding-potentials based on bio-kinetic modeling. Functional imaging has been frequently used in the context of auditory implantation. Before implantation it aims to assess intactness of the central auditory pathway and prognosis. After implantation it is used to improve understanding of the outcome with respect to auditory function and finally speech understanding, e.g. by measuring correlates of central auditory processing and neuroplasticity.

Keywords: Radiotracer imaging; PET; SPECT; cochlear implant; auditory brainstem implant; neuroplasticity

About the article

Published Online: 2017-09-07


Citation Information: Current Directions in Biomedical Engineering, Volume 3, Issue 2, Pages 187–190, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2017-0039.

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©2017 Georg Berding et al., published by De Gruyter. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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