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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.


CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

Open Access
Online
ISSN
2364-5504
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Mutual influence of incorporated drugs in a dual drug delivery coating for cardiovascular applications

Katharina Wulf
  • Corresponding author
  • University Medical Center Rostock, Institute for Biomedical Engineering, Friedrich-Barnewitz-Str. 4, D-18119 Rostock, Germany
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/ Michael Teske
  • University Medical Center Rostock, Institute for Biomedical Engineering, Friedrich-Barnewitz-Str. 4, D-18119 Rostock, Germany
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/ Claudia Matschegewski
  • University Medical Center Rostock, Institute for Biomedical Engineering, Friedrich-Barnewitz-Str. 4, D-18119 Rostock, Germany
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/ Daniela Arbeiter
  • University Medical Center Rostock, Institute for Biomedical Engineering, Friedrich-Barnewitz-Str. 4, D-18119 Rostock, Germany
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/ Thomas Eickner
  • University Medical Center Rostock, Institute for Biomedical Engineering, Friedrich-Barnewitz-Str. 4, D-18119 Rostock, Germany
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/ Klaus-Peter Schmitz / Niels Grabow
  • University Medical Center Rostock, Institute for Biomedical Engineering, Friedrich-Barnewitz-Str. 4, D-18119 Rostock, Germany
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Published Online: 2017-09-07 | DOI: https://doi.org/10.1515/cdbme-2017-0079

Abstract

For a long-term efficient drug-eluting stent for vascular applications, the development of drug-loaded coating, combining the effective inhibition of smooth muscle cell proliferation while promoting the re-endothelialization, is a promising concept. However the mostly required simultaneous incorporation of drugs can influence decisively the stability, efficacy and release of the respective drug. Therefore, the mutual influence of a dual local drug delivery coatings based on poly(L-lactide-co-ε-caprolactone) (PLLA-co-CL) containing vascular endothelial growth factor (VEGF165) coupled to the surface and an embedded drug, such as fluorescein diacetate (FDAc) instead of Paclitaxel (PTX) on the in vitro drug release was investigated. Surprisingly, for the investigated coating the immobilized VEGF loading was enhanced and the release profile was accelerated by FDAc incorporation. Even a manifold increase for the in vitro released amounts of VEGF was detected. In contrast, the immobilization of VEGF seems to have a negligible influence on the in vitro FDAc release profiles.

Keywords: Drug-eluting stent; PLLA; FDAc; VEGF

About the article

Published Online: 2017-09-07


Citation Information: Current Directions in Biomedical Engineering, Volume 3, Issue 2, Pages 379–382, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2017-0079.

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©2017 Katharina Wulf et al., published by De Gruyter. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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