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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.


CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

Open Access
Online
ISSN
2364-5504
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Agglomeration of magnetic nanoparticles and its effects on magnetic hyperthermia

Ulrich Engelmann
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  • Institute of Applied Medical Engineering RWTH Aachen University and University Hospital, Pauwelsstr. 20 D-52074 Aachen, Germany
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/ Eva Miriam Buhl / Martin Baumann
  • Institute of Applied Medical Engineering RWTH Aachen University and University Hospital, Pauwelsstr. 20 D-52074 Aachen, Germany
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/ Thomas Schmitz-Rode
  • Institute of Applied Medical Engineering RWTH Aachen University and University Hospital, Pauwelsstr. 20 D-52074 Aachen, Germany
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/ Ioana Slabu
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  • Institute of Applied Medical Engineering RWTH Aachen University and University Hospital, Pauwelsstr. 20 D-52074 Aachen, Germany
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Published Online: 2017-09-07 | DOI: https://doi.org/10.1515/cdbme-2017-0096

Abstract

Magnetic fluid hyperthermia (MFH) is a promising approach for organ-confined tumor treatment. In MFH, magnetic nanoparticles (MNP) are magnetically targeted at the tumor site and heated in an alternating magnetic field. The heat produced by the MNP is used to cause tumor cell death. At the tumor site, MNP bind to the cell membrane and form agglomerates before they are internalized into the intracellular compartments. Intracellular immobilization and the formation of agglomerates influence heating properties of MNP making it difficult to control the local heating inside the tumor. In this study, we investigated MNP agglomerated samples for their heating efficiency. We found an increase in heating of 22 % upon agglomeration. If MNP are additionally immobilized, however, the heating decreases by 30 %. Consequently, due to the binding of bigger MNP agglomerates at cellular level, heating efficiency inside tumors is assumed to decrease.

Keywords: magnetic iron-oxide nanoparticles; magnetic fluid hyperthermia; nanoparticle agglomeration

About the article

Published Online: 2017-09-07


Citation Information: Current Directions in Biomedical Engineering, Volume 3, Issue 2, Pages 457–460, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2017-0096.

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©2017 Ulrich Engelmann et al., published by De Gruyter. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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[1]
Ulrich M. Engelmann, Carolyn Shasha, Eric Teeman, Ioana Slabu, and Kannan M. Krishnan
Journal of Magnetism and Magnetic Materials, 2018
[2]
Ulrich M. Engelmann, Anjali A. Roeth, Dietmar Eberbeck, Eva M. Buhl, Ulf P. Neumann, Thomas Schmitz-Rode, and Ioana Slabu
Scientific Reports, 2018, Volume 8, Number 1
[3]
Ana Lorena Urbano-Bojorge, Oscar Casanova-Carvajal, Nazario Félix-González, Laura Fernández, Rodrigo Madurga, Santiago Sánchez-Cabezas, Elena Aznar, Milagros Ramos, and José Javier Serrano-Olmedo
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