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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.


CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

Open Access
Online
ISSN
2364-5504
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Radiofrequency applicator concepts for simultaneous MR imaging and hyperthermia treatment of glioblastoma multiforme

A 298 MHz (7.0 Tesla) thermal magnetic resonance simulation study

Eva Oberacker
  • Corresponding author
  • Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Centrum for Molecular Medicine in the Helmholtz Association, Robert-Rössle-Str. 10, 13125 Berlin, Germany
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Andre Kuehne / Jacek Nadobny / Sebastian Zschaeck / Mirko Weihrauch / Helmar Waiczies / Pirus Ghadjar / Peter Wust / Thoralf Niendorf
  • MRI.TOOLS GmbH, Berlin, Germany
  • Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Centrum for Molecular Medicine in the Helmholtz Association, Berlin, Germany
  • Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Lukas Winter
  • Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Centrum for Molecular Medicine in the Helmholtz Association, Berlin, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-09-07 | DOI: https://doi.org/10.1515/cdbme-2017-0100

Abstract

Glioblastoma multiforme is the most frequent and most aggressive malignant brain tumor with de facto no long term curation by the use of current multimodal therapeutic approaches. The efficacy of brachytherapy and enhancing interstitial hyperthermia has been demonstrated. RF heating at ultrahigh fields (B0=7.0T, f=298MHz) has the potential of delivering sufficiently large thermal dosage for hyperthermia of relatively large tumor areas. This work focuses on electromagnetic field (EMF) simulations and provides realistic applicator designs tailored for simultaneous RF heating and MRI. Our simulations took advantage of target volumes derived from patient data, and our preliminary results suggest that RF power can be focused to both a small tumor area and a large clinical target volume.

Keywords: Thermal Magnetic Resonance; RF heating; hyperthermia; glioblastoma multiforme; RF applicator

About the article

Published Online: 2017-09-07


Citation Information: Current Directions in Biomedical Engineering, Volume 3, Issue 2, Pages 473–477, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2017-0100.

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©2017 Eva Oberacker et al., published by De Gruyter. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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