Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.


CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

Open Access
Online
ISSN
2364-5504
See all formats and pricing
More options …

Impact of aortic root geometry on hydrody-namic performance of transcatheter aortic valve prostheses

Development of physiological and pathophysiological vessel models using additive manufacturing techniques

Sebastian Kaule
  • Corresponding author
  • Institute for ImplantTechnology and Biomaterials e.V., Friedrich- Barnewitz-Str. 4, 18119 Rostock-Warnemünde, Germany
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sylvia Pfensig
  • Institute for ImplantTechnology and Biomaterials e.V., Friedrich- Barnewitz-Str. 4, 18119 Rostock-Warnemünde, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Robert Ott
  • Institute for ImplantTechnology and Biomaterials e.V., Friedrich- Barnewitz-Str. 4, 18119 Rostock-Warnemünde, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Stefan Siewert
  • Institute for ImplantTechnology and Biomaterials e.V., Friedrich- Barnewitz-Str. 4, 18119 Rostock-Warnemünde, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Niels Grabow
  • Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Klaus-Peter Schmitz
  • Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Michael Stiehm
  • Institute for ImplantTechnology and Biomaterials e.V., Friedrich- Barnewitz-Str. 4, 18119 Rostock-Warnemünde, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-09-07 | DOI: https://doi.org/10.1515/cdbme-2017-0107

Abstract

Assessment of hydrodynamic performance of transcatheter aortic valve prostheses (TAVP) in vitro is es-sentially in the fields of development and approval of novel implants. For the prediction of clinical performance, in vitro testing of TAVP allows for benchmarking of different devic-es, likewise. In addition to the implant itself, also the testing environment has a crucial influence on leaflet dynamics and quantitative test results like effective orifice area (EOA) or aortic regurgitation.

Therefore, within the current study we developed simpli-fied physiological and pathophysiological vessel models of the aortic root as a tool for in vitro hydrodynamic testing of TAVP in idealized and worst case conditions. We used 3D printing and silicone cast molding for manufacturing of aortic root models with variable degree of stenosis. Design of aortic roots with normal, mild and severe stenosis was developed according to Reul et al. For manufacturing of tripartite cast-ing molds, a 3D printer was used. Both outer mold parts and the mold core were manufactured from polylactide filament and water soluble polyvinylalcohol filament, respectively. In vitro hydrodynamic performance testing of an exemplary commercially available TAVP implanted in different aortic root models was conducted according to DIN EN ISO 5840-3:2013, using a pulse duplicator system. Manufactured aortic root models were highly transparent, dimensionally stable and therefore suitable for hydrodynamic testing of TAVP. Both, EOA and regurgitant fraction in-creased with increasing degree of stenosis from 1.6 ± 0.1 cm2 to 1.8 ± 0.1 cm2 and 8.6 ± 6.5% to 20.2 ± 4.2% (n = 30 cy-cles), respectively.

We successfully developed a testing environment ena-bling sophisticated evaluation of hydrodynamic performance of TAVR in pathophysiological worst case conditions.

Keywords: Transcatheter Aortic Valve; hydrodynamic testing; additive manufacturing

About the article

Published Online: 2017-09-07


Citation Information: Current Directions in Biomedical Engineering, Volume 3, Issue 2, Pages 509–512, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2017-0107.

Export Citation

©2017 Sebastian Kaule et al., published by De Gruyter. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

Comments (0)

Please log in or register to comment.
Log in