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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.

CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

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Numerical flow simulation methods and additive manufacturing methods for the development of a flow optimised design of a novel point-of-care diagnostic device

Manuel Dethloff
  • Corresponding author
  • University of Rostock, Fluid Technology and Microfluidics, Justus-von-Liebig Weg 6, 18059 Rostock, Germany,
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/ Hermann Seitz / Marc Dangers
Published Online: 2017-09-07 | DOI: https://doi.org/10.1515/cdbme-2017-0129


For the development of a novel, user-friendly and low cost point-of-care diagnostic device for the detection of disease specific biomarker a flow optimised design of the test system has to be investigated. The resulting test system is characterised by a reduced execution period, a reduction of execution steps and an integrated waste management. Based on previous results, the current study focused on the design implementation of the fluidic requirements, e. g. tightness, inside the test device. With the help of fluid flow simulations (CFD – computational fluid dynamics) the flow behaviour inside the test device was analysed for different designs and arrangements. Prototypes generated from additive manufacturing technologies (PolyJet modeling) are used for validating the simulation results and further experimental tests.

Keywords: point-of-care diagnostic (POC); Line Immune-assay (LIA); computational fluid dynamics (CFD); additive manufacturing

About the article

Published Online: 2017-09-07

Citation Information: Current Directions in Biomedical Engineering, Volume 3, Issue 2, Pages 619–622, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2017-0129.

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©2017 Manuel Dethloff et al., published by De Gruyter. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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