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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.


CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

Open Access
Online
ISSN
2364-5504
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Promising biocompatible hydrogels of crosslinked polyelectrolytes for biomedical applications

Andreas Brietzke
  • Corresponding author
  • Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Straße 4, D-18119 Rostock, Germany
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/ Christian von der Ehe / Sabine Illner
  • Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Straße 4, D-18119 Rostock, Germany
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/ Claudia Matschegewski / Niels Grabow
  • Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Straße 4, D-18119 Rostock, Germany
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/ Udo Kragl
Published Online: 2017-09-07 | DOI: https://doi.org/10.1515/cdbme-2017-0147

Abstract

For the development of intelligent implant systems hydrogels (HG) from crosslinked ionic liquids feature a high potential to be utilised as a drug depot. Biocompatibility of the HGs is one key prerequisite for biomedical applications. HGs were polymerised from a variety of different ionic monomers based on methacrylate, methacrylamide, styrene or vinyl imidazolium derivatives in aqueous solution. N,N'-methylenebisacrylamide was used as crosslinker. CellQuanti-Blue™ Cell Viability Assay Kit was implemented to proof viability of L929 mouse fibroblasts. The predominant part of the HG eluates generated only a marginal reduction of less than 15% cell viability at 100% eluate concentration. This underlines the excellent suitability of these HGs for biomedical applications and revealed some promising candidates for the development of drug depots for implants.

Keywords: biocompatibility; hydrogel; ionic liquid; implant; drug depot

About the article

Published Online: 2017-09-07


Citation Information: Current Directions in Biomedical Engineering, Volume 3, Issue 2, Pages 695–698, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2017-0147.

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©2017 Andreas Brietzke et al., published by De Gruyter. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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