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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.


CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

Open Access
Online
ISSN
2364-5504
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Marker for the pre-clinical development of bone substitute materials

X-ray opaque histology cages for bone substitute testing

Michael de Wild
  • Corresponding author
  • University of Applied Sciences Northwestern Switzerland, FHNW, School of Life Sciences, Institute for Medical and Analytical Technologies, Gründenstrasse 40, CH-4132 Muttenz, Switzerland
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/ Simon Zimmermann
  • University of Applied Sciences Northwestern Switzerland, FHNW, School of Life Sciences, Institute for Medical and Analytical Technologies, Gründenstrasse 40, CH-4132 Muttenz, Switzerland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Marcel Obrecht / Michel Dard
  • Medical Affairs, Institut Straumann AG, Peter Merian-Weg 12, 4052 Basel, Switzerland
  • New York University, College of Dentistry, Department of Periodontology and Implant Dentistry, New York, USA
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2017-09-07 | DOI: https://doi.org/10.1515/cdbme-2017-0151

Abstract

Thin mechanically stable Ti-cages have been developed for the in-vivo application as X-ray and histology markers for the optimized evaluation of pre-clinical performance of bone graft materials. A metallic frame defines the region of interest during histological investigations and supports the identification of the defect site. This standardization of the procedure enhances the quality of pre-clinical experiments. Different models of thin metallic frameworks were designed and produced out of titanium by additive manufacturing (Selective Laser Melting). The productibility, the mechanical stability, the handling and suitability of several frame geometries were tested during surgery in artificial and in ex-vivo bone before a series of cages was preclinically investigated in the female Göttingen minipigs model. With our novel approach, a flexible process was established that can be adapted to the requirements of any specific animal model and bone graft testing.

Keywords: Histology; marker; titanium; preclinical study; X-ray opaque

About the article

Published Online: 2017-09-07


Citation Information: Current Directions in Biomedical Engineering, Volume 3, Issue 2, Pages 711–715, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2017-0151.

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©2017 Michael de Wild et al., published by De Gruyter. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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