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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.

CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

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Electrospinning for polymeric implants in cardiovascular applications

Accelerated Degradation of Electrospun Poly(L-lactide) Scaffolds

Stefanie Kohse
  • Corresponding author
  • University Medical Center Rostock, Institute for Biomedical Engineering, Friedrich- Barnewitz-Str. 4, D-18119 Rostock, Germany
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Daniela Arbeiter / Thomas Reske / Michael Stiehm / Klaus-Peter Schmitz
  • University Medical Center Rostock, Institute for Biomedical Engineering, Rostock, Germany and Institute for Implant Technology and Biomaterials e.V., Rostock, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Niels Grabow
Published Online: 2018-09-22 | DOI: https://doi.org/10.1515/cdbme-2018-0023


Electrospinning is a method for producing fibrous polymer scaffolds that can be applied in drug delivery systems as well as for polymer-based implants. Biodegradable polymers for the purpose of cardiac tissue engineering are often applied as fibrous scaffolds for morphological mimikry of natural matrices but also drugeluting approaches are very promising. Hydrolytic degradation is one of the key parameters for successful application. The focus of our investigations is on monitoring accelerated in vitro degradation of electrospun nonwoven scaffolds. In the presented study degradation of poly(Llactide) is accelerated by alkaline hydrolysis. The process is characterized by weight loss, loss of molecular mass, surface morphology and thermal behavior of nonwoven samples, showing a fast degradation of the fibrous material within two weeks.

Keywords: Electrospinning; degradation; acceleration

About the article

Published Online: 2018-09-22

Published in Print: 2018-09-01

Citation Information: Current Directions in Biomedical Engineering, Volume 4, Issue 1, Pages 89–92, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2018-0023.

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