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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.

Open Access
Online
ISSN
2364-5504
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Novel 3D printing concept for the fabrication of time-controlled drug delivery systems

Jan Konasch
  • Corresponding author
  • Fluid Technology and Microfluidics, University of Rostock, Justus-von-Liebig-Weg 6, 18059 Rostock, Germany
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/ Alexander Riess
  • Fluid Technology and Microfluidics, University of Rostock, Justus-von- Liebig-Weg 6, 18059 Rostock, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Michael Teske / Natalia Rekowska / Natalia Rekowska / Robert Mau / Thomas Eickner / Niels Grabow / Hermann Seitz
Published Online: 2018-09-22 | DOI: https://doi.org/10.1515/cdbme-2018-0035

Abstract

Three-dimensional (3D) printing has become a popular technique in many areas. One emerging field is the use of 3D printing for the development of 3D drug delivery systems (DDS) and drug-loaded medical devices. This article describes a novel concept for the fabrication of timecontrolled drug delivery systems based on stereolithography combined with inkjet printing. An inkjet printhead and an UV-LED light source have been integrated into an existing stereolithography system. Inkjet printing is used to selectively incorporate active pharmaceutical ingredients (API) during a stereolithographic 3D printing process. In an initial experimental study, poly (ethylene glycol) diacrylate (PEGDA) was used as polymer whereas 2-Hydroxy-4´-(2- hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) and Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) were used as photoinitiators. Basic structures could be manufactured successfully by the new hybrid 3D printing system.

Keywords: drug delivery system; stereolithography; inkjet printing; UV-LED; PEGDA; Irgacure 2959; LAP

About the article

Published Online: 2018-09-22

Published in Print: 2018-09-01


Citation Information: Current Directions in Biomedical Engineering, Volume 4, Issue 1, Pages 141–144, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2018-0035.

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