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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.


CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

Open Access
Online
ISSN
2364-5504
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Hemodynamic influence of design parameters of novel venous valve prostheses

Michael Stiehm
  • Corresponding author
  • Institute for ImplantTechnology and Biomaterials e.V., Friedrich- Barnewitz-Str. 4, 18119 Rostock- Warnemünde, Germany
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/ Stefanie Kohse
  • Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich- Barnewitz-Str. 4, 18119 Rostock- Warnemünde, Germany
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/ Kerstin Schümann
  • Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich- Barnewitz-Str. 4, 18119 Rostock- Warnemünde, Germany
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/ Sebastian Kaule
  • Institute for ImplantTechnology and Biomaterials e.V., Friedrich- Barnewitz-Str. 4, 18119 Rostock- Warnemünde, Germany
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/ Stefan Siewert
  • Institute for ImplantTechnology and Biomaterials e.V., Friedrich- Barnewitz-Str. 4, 18119 Rostock- Warnemünde, Germany
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/ Jan Oldenburg
  • Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich- Barnewitz-Str. 4, 18119 Rostock- Warnemünde, Germany
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/ Jonas Keiler
  • Department of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057 Rostock, Germany
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/ Niels Grabow
  • Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich- Barnewitz-Str. 4, 18119 Rostock- Warnemünde, Germany
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/ Andreas Wree
  • Department of Anatomy, Rostock University Medical Center, Gertrudenstr. 9, 18057 Rostock, Germany
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/ Klaus-Peter Schmitz
  • Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich- Barnewitz-Str. 4, 18119 Rostock- Warnemünde, Germany
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Published Online: 2018-09-22 | DOI: https://doi.org/10.1515/cdbme-2018-0037

Abstract

Venous ulcers of the lower limbs are one clinical manifestation of chronic venous insufficiency. Currently, there is no venous valve prosthesis available. This study presents novel venous valve prostheses made of threedimensional electrospun fibrous nonwoven leaflets. The aim of this study was to prove the feasibility of the manufacturing process as well as to investigate design features of the venous valve prostheses from a hemodynamic point of view. An adapted pulse duplicator system (ViVitrolabs, Victoria, BC, CA) was used for characterization of the hydrodynamic performance. For eight different venous valve prototypes flow rate, effective orifice area and regurgitation fraction was investigated in vitro. In particular, tricusp valve designs showed an up to 40% higher effective orifice area as well as 15% higher maximum flowrate compared to bicusp valve designs. However, the regurgitation fraction of the bicusp valve designs is up to 86% lower compared to tricusp valve. Additionally, the hemodynamic performance of the tricuspid valves showed a high sensitivity regarding the leaflet length. Bicuspid valves are less sensitive to changes of design parameters, more sufficient and therefore highly reliable.

Keywords: Venous valve prostheses; electrospinning; hemodynamic; regurgitation fraction

About the article

Published Online: 2018-09-22

Published in Print: 2018-09-01


Citation Information: Current Directions in Biomedical Engineering, Volume 4, Issue 1, Pages 149–151, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2018-0037.

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