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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.

Open Access
Online
ISSN
2364-5504
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Polymer drug release system for biofilm inhibition in medical application

Katharina Wulf
  • University Medical Center Rostock, Institute for Biomedical Engineering, Friedrich- Barnewitz-Str. 4, D-18119 Rostock, Germany
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/ Daniela Arbeiter / Thomas Eickner / Katharina Riedel
  • Ernst-Moritz-Arndt-University of Greifswald, Department of Microbial Physiology and Molecular Biology, Greifswald, Germany
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/ Klaus-Peter Schmitz
  • University Medical Center Rostock, Institute for Biomedical Engineering, Rostock, Germany and Institute for Implant Technology and Biomaterials e.V., Rostock, Germany
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/ Niels Grabow / Stefanie Kohse
Published Online: 2018-09-22 | DOI: https://doi.org/10.1515/cdbme-2018-0052

Abstract

Bacterial biofilm formation on surfaces is still a critical challenge regarding the application of implants. Generally, in order to avoid this, an additional systemic administration of antibiotics is given, which can lead to side effects, such as the reduction of the intestinal flora. Continuous treatment may lead to antibiotics resistance. Within this study we investigated the local drug delivery of N-acetyl-L-cysteine (NAC) from a Poly-L-lactide (PLLA) coating, an ished biodegradable polymer and a polyetherurethane (PEU) coating, a promising representative non-degradable polymer for cardiovascular applications as alternative to the administration of antibiotics. The incorporation of NAC influenced the surface properties of PEU in contrast to that of PLLA. The in vitro NAC release is almost completed after 24 h for PEU. For PLLA only small amounts of incorporated NAC, depending on the NAC loading, is released after a short time. Both systems are rather useful as local NAC delivery system directly after implantation.

Keywords: NAC; PEU; PLLA; in vitro release

About the article

Published Online: 2018-09-22

Published in Print: 2018-09-01


Citation Information: Current Directions in Biomedical Engineering, Volume 4, Issue 1, Pages 213–216, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2018-0052.

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