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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.

CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

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Soft tissue volume augmentation in the oral cavity with a collagen-based 3D matrix with orientated open pore structure

Leon Olde Damink / Ingo Heschel / Hans Leemhuis / Martina Tortorici
  • Julius Wolff Institut, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
  • Other articles by this author:
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/ Bastian Wessing
Published Online: 2018-09-22 | DOI: https://doi.org/10.1515/cdbme-2018-0058


In this study, characteristic features of a new regenerative 3D collagen matrix with an orientated open pore structure are studied in-vitro and in-vivo. The noncrosslinked porcine-based resorbable collagen-elastin matrix is designed to provide support during coverage procedures of localized gingival recessions and for local soft tissue augmentation around teeth and implants and is designed to provide an off-the-shelf alternative to autogenous soft tissue grafts. The in-vitro studies show that the mechanical properties (e.g. suture retention, volume recovery after cyclic compression) and the observed active cell migration into the open porous structure of the matrix fulfil essential design requirements. The in-vivo pig animal study shows that the matrix is well integrated into the surrounding tissue and replaced by newly formed autogenous soft tissue without a significant loss in tissue volume. First clinical case series are being performed to further analyse the new 3D matrix in clinical settings.

Keywords: biomaterials; collagen; 3D matrix; soft tissue augmentation; dental implants; guided tissue regeneration

About the article

Published Online: 2018-09-22

Published in Print: 2018-09-01

Citation Information: Current Directions in Biomedical Engineering, Volume 4, Issue 1, Pages 237–241, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2018-0058.

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