Current Directions in Biomedical Engineering
Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering
Editor-in-Chief: Dössel, Olaf
Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.
In vivo myocardial tissue characterization of all four chambers using high-resolution quantitative MRI
- Charité Medical Faculty University Medicine, Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center (ECRC), DZHK partner site Berlin, Germany
- Department of Cardiology and Nephrology, HELIOS Klinikum Berlin Buch, Berlin, Germany
- Other articles by this author:
- De Gruyter OnlineGoogle Scholar
Quantitative native T1 Mapping of the myocardium without the application of contrast agents can be used to detect fibrosis in the left ventricle. Spatial resolution of standard native T1 mapping is limited by cardiac motion and hence is not sufficient to resolve small myocardial structures, such as the right ventricle and the atria. Here, we present a novel MR approach which provides cardiac motion information and native T1 maps from the same data. Motion information is utilized to optimize data selection for T1 mapping and a model-based iterative reconstruction scheme ensures high-resolution T1 maps for the entire heart. Feasibility of the approach was demonstrated in three healthy volunteers. In the T1 maps, the myocardium of all four chambers can be visualized and T1 values of the left atrium and right chambers were comparable to left ventricular T1 values.