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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.


CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

Open Access
Online
ISSN
2364-5504
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In vitro study of sirolimus release from nonwoven PLLA matrices

Sabine Illner
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  • Institute for Biomedical Engineering, University Medical Center Rostock, Rostock- Warnemünde, Germany
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/ Stefanie Kohse
  • Institute for Biomedical Engineering, University Medical Center Rostock, Rostock- Warnemünde, Germany
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/ Claudia Michaelis
  • Institute for Biomedical Engineering, University Medical Center Rostock, Rostock- Warnemünde, Germany
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/ Thomas Reske
  • Institute for Biomedical Engineering, University Medical Center Rostock, Rostock- Warnemünde, Germany
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/ Niels Grabow
  • Institute for Biomedical Engineering, University Medical Center Rostock, Rostock- Warnemünde, Germany
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/ Klaus-Peter Schmitz
  • Institute for ImplantTechnology and Biomaterials e.V., Rostock, Germany
  • Institute for Biomedical Engineering, University Medical Center Rostock, Rostock- Warnemünde, Germany
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/ Thomas Eickner
  • Institute for Biomedical Engineering, University Medical Center Rostock, Rostock- Warnemünde, Germany
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Published Online: 2018-09-22 | DOI: https://doi.org/10.1515/cdbme-2018-0142

Abstract

Sirolimus incorporated nonwoven polymer matrices were fabricated via electrospinning. Release kinetics considering different fiber diameters and layer thicknesses were investigated. In vitro drug release profiles were evaluated by measuring the drug concentration in an established drug release medium (0.9% saline solution with additives, not buffered) at predetermined time points. Furthermore, an NH3-plasma pretreatment was examined to ensure complete wetting from the beginning of the study. In comparison to thin drug-loaded PLLA spray coatings it was shown that the release of sirolimus is diffusion- and degradation-controlled regardless of the surface-to-volume ratio, though fiber diameters or a hydrophilization can affect its release kinetics.

Keywords: drug release; fibrous material; nonwoven; film layer; surface modification; hydrophilization

About the article

Published Online: 2018-09-22

Published in Print: 2018-09-01


Citation Information: Current Directions in Biomedical Engineering, Volume 4, Issue 1, Pages 591–594, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2018-0142.

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