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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.


CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

Open Access
Online
ISSN
2364-5504
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Thermomechanical properties of PEGDA and its co-polymers

Natalia Rekowska
  • Corresponding author
  • Institute for Biomedical Engineering, University Medical Center Rostock, Friedrich-Barnewitz-Straße 4, 18119 Rostock, Germany
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/ Daniela Arbeiter / Jan Konasch / Alexander Riess / Robert Mau / Thomas Eickner / Hermann Seitz / Niels Grabow / Michael Teske
Published Online: 2018-09-22 | DOI: https://doi.org/10.1515/cdbme-2018-0161

Abstract

Current research activities focus on personalized, comfortable and safe products for systemic or local drug application in patients. Poly(ethylene glycol) diacrylate is in particular interest as a drug delivery material, as it shows appropriate biological properties such as hydrophilicity and low toxicity. Additionally, as an easily photopolymerizable compound it can be also utilized for the production of scaffolds with the use of different techniques such as stereolithography. Even though it is often used as a biomaterial or as a copolymer in many photopolymer systems for drug delivery, thermomechanical analysis and basic understanding are rare.

Therefore, we investigated the tensile stress and the glass transition temperature of pure PEGDA and of its copolymers with 1,3-butanediol diacrylate or pentaerythritol triacrylate, as a function of the photoinitiator (PI) or acrylate concentration. Additionally, we demonstrated that the washing procedure decreases the tensile stress values. We showed, that by the means of composing PEGDA with these, it is possible to influence thermomechanical properties of the sample. Our outcomes have revealed, that there is no clear influence of the PI concentration on the thermomechanical properties. However there is an influence of the monomer concentration. Therefore, it should be possible to modify drug release profiles in future experiments.

Keywords: Drug delivery system; Poly(ethylene glycol) diacrylate (PEGDA); 1,3-butanediol diacrylate; pentaerythritol triacrylate; photopolymerisation; glass transition temperature; mechanical properties

About the article

Published Online: 2018-09-22

Published in Print: 2018-09-01


Citation Information: Current Directions in Biomedical Engineering, Volume 4, Issue 1, Pages 669–672, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2018-0161.

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© 2018 Natalia Rekowska, Daniela Arbeiter, Jan Konasch, Alexander Riess, Robert Mau, Thomas Eikner, Herman Seitz, Niels Grabow, Michael Teske, published by Walter de Gruyter Berlin/Boston. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. BY-NC-ND 4.0

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[1]
Jan Konasch, Alexander Riess, Robert Mau, Michael Teske, Natalia Rekowska, Thomas Eickner, Niels Grabow, and Hermann Seitz
Pharmaceutics, 2019, Volume 11, Number 12, Page 661

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