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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.


CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

Open Access
Online
ISSN
2364-5504
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Development of an antifibrotic drug-eluting coating for a minimally invasive implantable glaucoma microstent

Stefan Siewert
  • Corresponding author
  • Institute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, Rostock- Warnemünde, Germany
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/ Thomas Reske / Sylvia Pfensig / Swen Großmann / Michael Stiehm / Klaus-Peter Schmitz
  • Institute for ImplantTechnology and Biomaterials e.V., Rostock- Warnemünde, Germany
  • Institute for Biomedical Engineering, Rostock University Medical Center, Rostock- Warnemünde, Germany
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/ Wolfram Schmidt
  • Institute for Biomedical Engineering, Rostock University Medical Center, Rostock- Warnemünde, Germany
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  • De Gruyter OnlineGoogle Scholar
/ Niels Grabow
  • Institute for Biomedical Engineering, Rostock University Medical Center, Rostock- Warnemünde, Germany
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/ Thomas Stahnke / Rudolf Guthoff
Published Online: 2019-09-18 | DOI: https://doi.org/10.1515/cdbme-2019-0055

Abstract

Primary open angle glaucoma represents an eye disease that usually is associated with an increased intraocular pressure (IOP). Implants for micro-invasive glaucoma surgery (MIGS) are gaining importance as a promising option for IOP lowering. Currently available devices are implanted into the eye ab interno based on a clear corneal incision and drain aqueous humour into the schlemm’s canal, suprachoroidal or subconjunctival space. Fibrosis is known as a major limitation for long term success and often leads to the necessity of an additional medication or a surgical re-intervention. The current work focusses on the development of an antifibrotic drug-eluting coating for a minimally invasive implantable glaucoma microstent. Tubular microstent base bodies manufactured from a polycarbonate based silicone elastomer were spray-coated with a chloroform based mixture of the same polymer and the antifibrotic drug pirfenidone (PFD, P2116, Merck KGaA, Germany) in a polymer/drug ratio of 85/15% (w/w). Coating mass of 89 μg according to a drug loading of 1.96 μg mm-2 was aspired. Coating mass was measured using an ultramicrobalance (XP6U, Mettler-Toledo International, Inc., Switzerland). Glaucoma microstent prototypes with a drugeluting coating mass of (84 ± 19) μg (n = 12) were manufactured. Characterization by means of scanning electron microscopy (Quattro S, Thermo Fisher Scientific, FEI Deutschland GmbH, Germany) yielded a reproducible smooth surface of the coating. High performance liquid chromatography (KNAUER Wissenschaftliche Geräte GmbH, Germany) was used for analysis of drug release behaviour in 0.9% NaCl solution at 37°C. The in vitro PFDrelease is characterized by an initial burst phase of approximately 6 h followed by a more retarded release phase. The entire drug was released within 36 h (n = 3). Sterilization processing has a minor impact on drug release kinetics. Appropriate drug stability after sterilization could be proven. Future studies will focus on the antifibrotic properties of drug-eluting glaucoma microstents in animal studies.

Keywords: Glaucoma drainage device; GDD; Minimally invasive glaucoma surgery; Micro-invasive glaucoma surgery; MIGS

About the article

Published Online: 2019-09-18

Published in Print: 2019-09-01


Citation Information: Current Directions in Biomedical Engineering, Volume 5, Issue 1, Pages 215–218, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2019-0055.

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© 2019 by Walter de Gruyter Berlin/Boston. This work is licensed under the Creative Commons Attribution 4.0 Public License. BY 4.0

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