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Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.


CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

Open Access
Online
ISSN
2364-5504
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Numerical simulation of the functionality of a stent structure for venous valve prostheses

Julia Schubert
  • Corresponding author
  • Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich- Barnewitz-Str. 4, Rostock- Warnemünde, Germany
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/ Kerstin Schümann
  • Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock- Warnemünde, Germany
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/ Sabine Kischkel
  • Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock- Warnemünde, Germany
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/ Wolfram Schmidt
  • Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock- Warnemünde, Germany
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/ Niels Grabow
  • Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock- Warnemünde, Germany
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/ Michael Stiehm
  • Institute for ImplantTechnology and Biomaterials – IIB e.V. and Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, Rostock Warnemünde, Germany
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/ Sylvia Pfensig
  • Institute for ImplantTechnology and Biomaterials - IIB e.V. and Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, Rostock Warnemünde, Germany
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/ Klaus-Peter Schmitz
  • Institute for ImplantTechnology and Biomaterials - IIB e.V. and Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, Rostock Warnemünde, Germany
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/ Jonas Keiler / Andreas Wree
Published Online: 2019-09-18 | DOI: https://doi.org/10.1515/cdbme-2019-0120

Abstract

Chronic venous insufficiency (CVI) is a common disease characterized by impaired venous drainage leading to congestion in the lower limbs. Currently, there are no artificial or biological venous valve prostheses commercially available. Previous minimally invasive design concepts failed to achieve sufficient long term results in animal or in vitro studies. The aim was to implement structural numerical simulation of clinically relevant loading cases for minimally invasive implantable venous valve prostheses. A bicuspid valve design was chosen as it showed superior results compared to tricuspid valves in previous studies. The selfexpanding support structure was developed by using diamond-shaped elements. Using finite-element analysis (FEA), various loading cases, including expansion and crimping of the stent structure and the release into a venous vessel, were simulated. A hyperelastic constitutive law for the vascular model was generated from uniaxial tensile test data of unfixated human vein walls. This study also compared numerical and experimental results regarding compliance and tensile tests to validate the vein material model. The calculated performance concerning expansion and crimping, as well as the release of the stent into a venous vessel, demonstrated the suitability of the stent design for minimally invasive application.

Keywords: Finite-element analysis; venous valve prosthesis; venous material model

About the article

Published Online: 2019-09-18

Published in Print: 2019-09-01


Citation Information: Current Directions in Biomedical Engineering, Volume 5, Issue 1, Pages 477–479, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2019-0120.

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© 2019 by Walter de Gruyter Berlin/Boston. This work is licensed under the Creative Commons Attribution 4.0 Public License. BY 4.0

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