Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Current Directions in Biomedical Engineering

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Buzug, Thorsten M. / Haueisen, Jens / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Kraft, Marc / Lenarz, Thomas / Leonhardt, Steffen / Malberg, Hagen / Penzel, Thomas / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Urban, Gerald A.


CiteScore 2018: 0.47

Source Normalized Impact per Paper (SNIP) 2018: 0.377

Open Access
Online
ISSN
2364-5504
See all formats and pricing
More options …

Development of a constitutive law for numerical simulation of artificial leaflet-structures for transcatheter heart valve prostheses

Sylvia Pfensig
  • Corresponding author
  • Institute for Implant- Technology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, Rostock- Warnemünde, Germany
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Daniela Arbeiter
  • Institute for Biomedical Engineering, Rostock University Medical Center, Rostock- Warnemünde, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Stefanie Kohse
  • Institute for Biomedical Engineering, Rostock University Medical Center, Rostock- Warnemünde, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Niels Grabow
  • Institute for Biomedical Engineering, Rostock University Medical Center, Rostock- Warnemünde, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Klaus-Peter Schmitz
  • Institute for Biomedical Engineering, Rostock University Medical Center, Rostock- Warnemünde, Germany
  • Institute for ImplantTechnology and Biomaterials e.V., Rostock- Warnemünde, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sebastian Kaule / Michael Stiehm / Stefan Siewert
Published Online: 2019-09-18 | DOI: https://doi.org/10.1515/cdbme-2019-0143

Abstract

While the current generation of devices for minimally invasive treatment of severe symptomatic aortic valve stenosis is based on xenogenic leaflet-material, artificial polymeric leaflet-structures represent a promising approach for future improvement of heart valve performance. For enhanced long-term success of polymeric leafletstructures, limitations regarding calcification and durability have to be addressed. The objective of the presented study was the development of a constitutive law representing the material properties of artificial polymeric leaflet-structures of transcatheter heart valve prostheses in numerical simulation to assess the in silico leaflet-performance. Mechanical characterization of cast films and nonwoven specimens of a polycarbonate based silicone elastomer were conducted by means of uniaxial tension and planar shear testing, respectively. For validation purposes, experimental data were compared with the results of finite-element analysis (FEA) using different hyperelastic models. Strain energy function for third-order ogden hyperelastic model achieved the best fit of the non-linear stress-strain behavior of the isotropic polymeric material with the experimental data. It was chosen for further FEA of valve leaflet-performance under physiological pressurization to analyze the suitability of various manufacturing processes for polymeric leafletstructures. Therefore a specific leaflet-design with a wall thickness of 400 μm was used. As a result of FEA, time dependent leaflet-deformation, leaflet coaptation surface area (CSA) and leaflet opening area (LOA) of cast and nonwoven leaflet-structures were calculated. While LOA was comparable for cast and nonwoven leaflet-structures, obtained leaflet-dynamics in a cardiac cycle under physiological pressurization demonstrated crucial influence of the manufacturing process. For nonwoven leafletstructures, an enhanced CSA could be demonstrated in comparison to cast structures. FEA using a validated hyperelastic constitutive law represents a useful tool for in silico performance evaluation of polymeric leaflet-structures under physiological loading and proves the suitability of the polymeric artificial leaflet-material for percutaneous heart valve prostheses.

Keywords: Finite-element analysis; transcatheter heart valve prosthesis; polymeric leaflet-structures; constitutive law

About the article

Published Online: 2019-09-18

Published in Print: 2019-09-01


Citation Information: Current Directions in Biomedical Engineering, Volume 5, Issue 1, Pages 569–572, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2019-0143.

Export Citation

© 2019 by Walter de Gruyter Berlin/Boston. This work is licensed under the Creative Commons Attribution 4.0 Public License. BY 4.0

Comments (0)

Please log in or register to comment.
Log in