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formerly Central European Journal of Chemistry

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Volume 3, Issue 4


Volume 13 (2015)

Synthesis, structural and conformational study of selected N-substituted phthalimides

Isabel Iriepa
  • Dpto. Química Orgánica, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares, Madrid, Spain
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/ F. Javier Villasante
  • Dpto. Química Orgánica, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares, Madrid, Spain
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/ Enrique Gálvez
  • Dpto. Química Orgánica, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares, Madrid, Spain
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/ Antonio Herrera / Angel Sánchez / Felix Cano
Published Online: 2005-12-01 | DOI: https://doi.org/10.2478/BF02475197


This paper synthesizes N-substituted phthalimides derived from nitrogen heterocycles as potential 5-HT4 ligands by using the Mitsunobu reaction. Conformational studies of some of the new compounds have been conducted using 1H and 13C-NMR spectroscopy. Proton and carbon resonances were achieved through the application of one-dimensional selective NOE, two-dimensional NMR techniques-homonuclear COSY-45, NOESY and heteronuclear 1H-13C HMQC correlated spectroscopy- and double resonance experiments. The crystal structure of compound 1 was determined by X-ray diffraction.

Keywords: Phthalimides; NMR spectroscopy; structural analysis

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About the article

Published Online: 2005-12-01

Published in Print: 2005-12-01

Citation Information: Open Chemistry, Volume 3, Issue 4, Pages 683–704, ISSN (Online) 2391-5420, DOI: https://doi.org/10.2478/BF02475197.

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