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Open Chemistry

formerly Central European Journal of Chemistry


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Volume 7, Issue 4

Issues

Volume 13 (2015)

Two charge-transfer complex spectrophotometric methods for the determination of sulpiride in pharmaceutical formulations

Sayed Zayed
Published Online: 2009-10-06 | DOI: https://doi.org/10.2478/s11532-009-0091-2

Abstract

Two simple, rapid, accurate and sensitive spectrophotometric methods are described for the determination of sulpiride. They are based on charge transfer complexation between the drug as n-electron donor and p-chloranilic acid as π acceptor or iodine as σ-acceptor. These give highly coloured complexes with absorption maxima at 518 and 363, 294 nm, respectively. Beer’s law linear ranges were 13.7–341.4 and 1.7–20.5 µg mL−1 for the p-chloranilic acid and iodine methods. The methods were successfully applied to the determination of the drug in Dogmatil® Fort tablets and the results compared with the official method. The complex association constants and standard free energy changes were calculated using Benesi-Hildebrand plots.

Keywords: Spectrophotometric determination; Sulpiride; p-chloranilic acid; Iodine; Charge-transfer complexes

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About the article

Published Online: 2009-10-06

Published in Print: 2009-12-01


Citation Information: Open Chemistry, Volume 7, Issue 4, Pages 870–875, ISSN (Online) 2391-5420, DOI: https://doi.org/10.2478/s11532-009-0091-2.

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© 2009 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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