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Open Chemistry

formerly Central European Journal of Chemistry


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Volume 11, Issue 12

Issues

Volume 13 (2015)

Synthesis, characterization and bioevaluation of irinotecan-collagen hybrid materials for biomedical applications as drug delivery systems in tumoral treatments

Georgeta Voicu
  • Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania
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  • De Gruyter OnlineGoogle Scholar
/ Ruxandra Geanaliu
  • Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania
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  • De Gruyter OnlineGoogle Scholar
/ Cristina Ghiţulică
  • Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania
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  • De Gruyter OnlineGoogle Scholar
/ Anton Ficai
  • Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania
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  • De Gruyter OnlineGoogle Scholar
/ Alexandru Grumezescu
  • Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania
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  • De Gruyter OnlineGoogle Scholar
/ Coralia Bleotu
Published Online: 2013-09-26 | DOI: https://doi.org/10.2478/s11532-013-0341-1

Abstract

The purpose of the present study is the preparation and characterization of collagen/antitumor drug hybrids as drug delivery systems. Materials used for obtaining collagen-based drug delivery systems were collagen type I (Coll) as matrix and irinotecan (I) as hydrophilic active substances. After incorporation of I into Coll in differing ratios, the obtained hybrid materials (Coll/I) could be used according to our results as potential drug delivery systems in medicine for the topical (local) treatment of cancerous tissues or bone. The released amount of I varies with amount of Coll from hybrid materials: the higher, the slower the release amount of irinotecan transferred is in the first 6 hours. The in vitro citotoxicity demonstrates an antitumoral activity of the obtained hybrid materials and their potential use for biomedical applications as drug delivery systems in tumoral treatments.

Keywords: Collagen; Irinotecan; Hybrid materials; Drug delivery system

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About the article

Published Online: 2013-09-26

Published in Print: 2013-12-01


Citation Information: Open Chemistry, Volume 11, Issue 12, Pages 2134–2143, ISSN (Online) 2391-5420, DOI: https://doi.org/10.2478/s11532-013-0341-1.

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