Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Open Chemistry

formerly Central European Journal of Chemistry

1 Issue per year


IMPACT FACTOR 2016 (Open Chemistry): 1.027
IMPACT FACTOR 2016 (Central European Journal of Chemistry): 1.460

CiteScore 2016: 0.61

SCImago Journal Rank (SJR) 2016: 0.288
Source Normalized Impact per Paper (SNIP) 2016: 0.735

Open Access
Online
ISSN
2391-5420
See all formats and pricing
More options …
Volume 11, Issue 3 (Mar 2013)

Issues

Separation of ketoprofen enantiomers at nanomolar concentration levels by micellar electrokinetic chromatography with on-line electrokinetic preconcentration

Jan Petr
  • Regional Centre of Advanced Technologies and Materials, Department of Analytical Chemistry, Faculty of Science, Palacký University in Olomouc, CZ-77146, Olomouc, Czech Republic
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Pavlína Ginterová
  • Regional Centre of Advanced Technologies and Materials, Department of Analytical Chemistry, Faculty of Science, Palacký University in Olomouc, CZ-77146, Olomouc, Czech Republic
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Joanna Znaleziona
  • Regional Centre of Advanced Technologies and Materials, Department of Analytical Chemistry, Faculty of Science, Palacký University in Olomouc, CZ-77146, Olomouc, Czech Republic
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Radim Knob
  • Department of Analytical Chemistry, Faculty of Science, Palacký University in Olomouc, CZ-77146, Olomouc, Czech Republic
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Markéta Lošťáková / Vítězslav Maier
  • Regional Centre of Advanced Technologies and Materials, Department of Analytical Chemistry, Faculty of Science, Palacký University in Olomouc, CZ-77146, Olomouc, Czech Republic
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Juraj Ševčík
  • Department of Analytical Chemistry, Faculty of Science, Palacký University in Olomouc, CZ-77146, Olomouc, Czech Republic
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-12-28 | DOI: https://doi.org/10.2478/s11532-012-0177-0

Abstract

Abstract Separation of enantiomers represents an extremely important task in the field of analytical chemistry. This paper contributes to the field of the on-line preconcentration of enantiomers by developing a novel setup based on the electrokinetic accumulation of ketoprofen enantiomers on the pH boundary followed by enantioselective mobilization by a mixture of SDS, sulfated-β-cyclodextrin (S-β-CD), and trimethyl-β-cyclodextrin (TM-β-CD). Under the best conditions, where the injection electrolyte was composed of 50 mmol L−1 borate/NaOH pH 9.5 with 60% (v/v) methanol, the background electrolyte contained 50 mmol L−1 phosphate/NaOH pH 2.5, and the mobilization electrolyte consisted of 50 mmol L−1 phosphate/NaOH pH 2.5 with 4.0% (w/v) S-β-CD, 0.5% (w/v) TM-β-CD, and 20 mmol L−1 SDS, the determination of nanomolar concentration levels of ketoprofen enantiomers was successful by using micellar electrokinetic chromatography with a common UV detection. LODs were 2.5 nmol L−1 and 3.4 nmol L−1, which represent enhancement factors of 9921 and 8529, respectively. The method was also applied to the determination of ketoprofen enantiomers in waste water samples by using simple filtration as a clean-up step. Here, the recovery of ketoprofen enantiomers was 91% at the concentration level of 5×10−9 mol L−1. Graphical abstract

Keywords: Capillary electrophoresis; Chiral separation; On-line preconcentration; Ketoprofen

  • [1] L. Pasteur, Ann. Chim. Phys. 24, 442 (1848) Google Scholar

  • [2] T.J. Ward, K.D. Ward, Anal. Chem. 28, 4712 (2010) http://dx.doi.org/10.1021/ac1010926CrossrefGoogle Scholar

  • [3] P. Mikuš, K. Maráková, Electrophoresis 30, 2773 (2009) http://dx.doi.org/10.1002/elps.200900173CrossrefGoogle Scholar

  • [4] G.K.E. Scriba, J. Sep. Sci. 31, 1991 (2008) http://dx.doi.org/10.1002/jssc.200800095CrossrefGoogle Scholar

  • [5] E. Tesařová, J. Ševčík, B. Gaš, D.W. Armstrong, Electrophoresis 25, 2693 (2004) http://dx.doi.org/10.1002/elps.200405972CrossrefGoogle Scholar

  • [6] J. Petr, V. Maier, J. Horáková, J. Ševčík, Electrophoresis 27, 4735 (2006) http://dx.doi.org/10.1002/elps.200600063CrossrefGoogle Scholar

  • [7] Z. Malá, P. Gebauer, P. Boček, Electrophoresis 32, 116 (2011) http://dx.doi.org/10.1002/elps.201000327CrossrefGoogle Scholar

  • [8] M.C. Breadmore, M. Dawod, J.P. Quirino, Electrophoresis 32, 127 (2011) http://dx.doi.org/10.1002/elps.201000412CrossrefGoogle Scholar

  • [9] P. Britz-McKibbin, D.D.Y. Chen, Anal. Chem. 72, 1242 (2000) http://dx.doi.org/10.1021/ac990898eCrossrefGoogle Scholar

  • [10] J. Horáková, J. Petr, V. Maier, E. Tesařová, L. Veis, D.W. Armstrong, B. Gaš, J. Ševčík, Electrophoresis 28, 1540 (2007) http://dx.doi.org/10.1002/elps.200600681CrossrefGoogle Scholar

  • [11] J. Petr, K. Vítková, V. Ranc, J. Znaleziona, V. Maier, R. Knob, J. Ševčík, J. Agric. Food Chem. 56, 3940 (2008) http://dx.doi.org/10.1021/jf8000179CrossrefGoogle Scholar

  • [12] K. Vítková, J. Petr, V. Maier, J. Znaleziona, J. Ševčík, Electrophoresis 31, 2771 (2010) http://dx.doi.org/10.1002/elps.200900663CrossrefGoogle Scholar

  • [13] A.S. Stasinakis, S. Mermigka, V.G. Samaras, E. Farmaki, N.S. Thomaidis, Env. Sci. Pollut. Res. 19, 1574 (2012) http://dx.doi.org/10.1007/s11356-011-0661-7CrossrefGoogle Scholar

  • [14] D. Bendz, N.A. Paxeus, T.R. Ginn, F.J. Loge, J. Hazard. Mat. 122, 195 (2005) http://dx.doi.org/10.1016/j.jhazmat.2005.03.012CrossrefGoogle Scholar

  • [15] N.H. Hashim, S.J. Khan, J. Chromatogr. A 1218, 4746 (2011) http://dx.doi.org/10.1016/j.chroma.2011.05.046CrossrefGoogle Scholar

  • [16] J. Safra, M. Pospisilova, J. Pharm. Biomed. Anal. 48, 452 (2008) http://dx.doi.org/10.1016/j.jpba.2008.01.030CrossrefGoogle Scholar

  • [17] I. Botello, F. Borrull, C. Aguilar, M. Calull, Electrophoresis 31, 2964 (2010) http://dx.doi.org/10.1002/elps.201000184CrossrefGoogle Scholar

  • [18] F.K. Glowka, M. Karazniewicz-Lada, Chromatographia 67, S97 (2008) http://dx.doi.org/10.1365/s10337-007-0483-4CrossrefGoogle Scholar

  • [19] M. Blanco, J.M. Gonzáles, E. Torras, I. Valverde, Anal. Bioanal. Chem. 375, 157 (2003) Google Scholar

  • [20] M. Blanco, J. Coelho, H. Iturriaga, S. Maspoch, C. Perez-Maseda, J. Chromatogr. A 793, 165 (1998) http://dx.doi.org/10.1016/S0021-9673(97)00893-5CrossrefGoogle Scholar

  • [21] Z.Y. Wang, J.F. Wang, Z.D. Hu, J.W. Kang, Electrophoresis 28, 938 (2007) http://dx.doi.org/10.1002/elps.200600514CrossrefGoogle Scholar

  • [22] C. Perrin, Y. Vander-Heyden, M. Maftouh, D.L. Massart, Electrophoresis 22, 3203 (2001) http://dx.doi.org/10.1002/1522-2683(200109)22:15<3203::AID-ELPS3203>3.0.CO;2-GCrossrefGoogle Scholar

  • [23] A.M. Abushoffa, M. Fillet, P. Hubert, J. Crommen, J. Chromatogr. A 948, 321 (2002) http://dx.doi.org/10.1016/S0021-9673(01)01371-1CrossrefGoogle Scholar

  • [24] K.J. Mysels, R.J. Otter, J. Colloid Sci. 16, 462 (1961) http://dx.doi.org/10.1016/0095-8522(61)90023-XCrossrefGoogle Scholar

  • [25] F. Melani, I. Giannini, B. Pasquini, S. Orlandini, S. Pinzauti, S. Furlanetto, Electrophoresis 32, 3062 (2011) http://dx.doi.org/10.1002/elps.201100263CrossrefGoogle Scholar

About the article

Published Online: 2012-12-28

Published in Print: 2013-03-01


Citation Information: Open Chemistry, ISSN (Online) 2391-5420, DOI: https://doi.org/10.2478/s11532-012-0177-0.

Export Citation

© 2012 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Ioannis J. Stavrou, Maria C. Mavroudi, and Constantina P. Kapnissi-Christodoulou
ELECTROPHORESIS, 2015, Volume 36, Number 1, Page 101
[2]
L. Escuder-Gilabert, Y. Martín-Biosca, M.J. Medina-Hernández, and S. Sagrado
Journal of Chromatography A, 2014, Volume 1357, Page 2
[3]
Laura Sánchez-Hernández, Miguel Guijarro-Diez, María Luisa Marina, and Antonio L. Crego
ELECTROPHORESIS, 2014, Volume 35, Number 1, Page 12

Comments (0)

Please log in or register to comment.
Log in