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Open Chemistry

formerly Central European Journal of Chemistry

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Volume 11, Issue 6

Issues

Volume 13 (2015)

A TLC Study of the lipophilicity of thirty-two acetylcholinesterase inhibitors — 1,2,3,4-tetrahydroacridine and 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives

Paweł Szymański / Robert Skibiński / Małgorzata Liszka / Izabela Jargieło / Elżbieta Mikiciuk-Olasik / Łukasz Komsta
Published Online: 2013-03-28 | DOI: https://doi.org/10.2478/s11532-013-0218-3

Abstract

The lipophilicity of thirty-two novel acetylcholinesterase (AChE) inhibitors — 1,2,3,4-tetrahydroacridine and 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives was studied by thin layer chromatography. The analyzed compounds were chromatographed on RP-18, RP-8, RP-2, CN and NH2 stationary phases with dioxane — citric buffer pH 3.0 binary mobile phases containing different proportions of dioxane. RM values for pure water were extrapolated from the linear Soczewiński-Wachtmeister equation and six compounds with known literature log P values were used as reference calibration data set for computation of experimental log P values. The obtained results were compared with computationally calculated partition coefficients values (AlogPs, AClogP, AlogP, MlogP, KOWWIN, XlogP2, XlogP3) by PCA and significant differences between them were observed.

Keywords: Lipophilicity; Calculated partition coefficients; AChE inhibitors; Tetrahydroacridine; Cyclopenta[b]quinoline

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About the article

Published Online: 2013-03-28

Published in Print: 2013-06-01


Citation Information: Open Chemistry, Volume 11, Issue 6, Pages 927–934, ISSN (Online) 2391-5420, DOI: https://doi.org/10.2478/s11532-013-0218-3.

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© 2013 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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