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Open Chemistry

formerly Central European Journal of Chemistry

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Volume 11, Issue 7

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Five different columns in the analysis of basic drugs in hydrophilic interaction liquid chromatography

Marko Jovanović / Biljana Stojanović / Tijana Rakić / Anđelija Malenović / Darko Ivanović / Mirjana Medenica
  • Department of Physical Chemistry and Instrumental Methods, University of Belgrade — Faculty of Pharmacy, 11221, Belgrade, Serbia
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Published Online: 2013-04-26 | DOI: https://doi.org/10.2478/s11532-013-0245-0

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Abstract

Five different columns (two silica, two cyanopropyl and one diol) were investigated in hydrophilic interaction liquid chromatography (HILIC). For the assessment of columns behavior in HILIC mode, six basic drugs (lamotrigine, thioridazine, clozapine, chlorpheniramine, pheniramine and sulpiride) were chosen. The assessment of the influence of the concentration of organic modifier on analytes’ retention on each column was provided by fitting the retention data into theoretical models. Utilizing the statistical analysis, the selection of the model that provides better prediction of the retention behavior was enabled. Dual RP-HILIC mechanism was suggested on cyanopropyl and diol columns, therefore the transition points between the two mechanisms on these columns were calculated. Furthermore, in order to investigate the impact of three factors simultaneously on the retention behavior of the analyzed substances on Betasil Silica column, chemometrically-aided empirical models were built. The experiments were conducted according to the matrix of Box-Behnken design and on the basis of the retention data, six quadratic models were obtained and their adequacy was confirmed using ANOVA test. The obtained coefficients of quadratic models enabled the elucidation of both single factor and factor interactions influence. This was also graphically presented in 3D response surface plots.

Keywords: Hydrophilic interaction chromatography; Retention prediction; Retention behavior; Basic drugs; Box-Behnken design

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About the article

Published Online: 2013-04-26

Published in Print: 2013-07-01

Citation Information: Open Chemistry, Volume 11, Issue 7, Pages 1150–1162, ISSN (Online) 2391-5420, DOI: https://doi.org/10.2478/s11532-013-0245-0.

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© 2013 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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