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Open Chemistry

formerly Central European Journal of Chemistry

1 Issue per year


IMPACT FACTOR 2016 (Open Chemistry): 1.027
IMPACT FACTOR 2016 (Central European Journal of Chemistry): 1.460

CiteScore 2016: 0.61

SCImago Journal Rank (SJR) 2016: 0.288
Source Normalized Impact per Paper (SNIP) 2016: 0.735

Open Access
Online
ISSN
2391-5420
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Volume 13, Issue 1 (Nov 2014)

Issues

The influence of Ki-67 proliferation index on Tc-99m-EDDA-HYNIC-TOC somatostatin receptor scintigraphy in patients with carcinoids

Marina Vlajković
  • Corresponding author
  • Faculty of Medicine, Center of Nuclear Medicine, Clinical Center Niš, 18000 Niš, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Milena Rajić / Slobodan Ilić / Miloš Stević / Marko Kojić / Vesna Živković
  • Faculty of Medicine, Clinic of Physical Medicine, Rehabilitation and Prosthetics, Clinical Center Niš, 18000 Niš, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Aleksandar Karanikolić / Milovan Matović
  • Faculty of Medicine, Center of Nuclear Medicine, Clinical Center Kragujevac, 34000 Kragujevac, Serbia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2014-11-26 | DOI: https://doi.org/10.1515/chem-2015-0042

Abstract

The aim of this paper is to determine the influence of Ki-67 proliferation index on somatostatin receptor scintigraphy (SSRS) with Tc-99m-EDDA-HYNIC-TOC (Tc-99m-Tektrotyd) somatostatin analogue in patients with carcinoid tumors. Sixty-one patients (31 female, 30 male; age range: 33-76 years) were examined: 13 patients highly suspected of having a carcinoid, and 48 patients who had undergone the surgical removal of the tumor. Whole body SSRS at 4 h postinjection, spot scintigrams and SPECT of the selected regions were obtained for all patients. Tc-99m-Tektrotyd scintigraphy was classified as true positive in 26 out of 30 and true negative in 24 out of 28 patients. The sensitivity of Tc-99mTc-Tektrotyd scintigraphy was found to be as high as 94.74% in the group of patients with low mitotic index Ki67 (<2%), and it progressively decreased in patients with higher mitotic index (77.78% for Ki67 2-15% and 20% for Ki67% >20%). The likelihood of Tc-99m-Tektrotyd scan being positive when a carcinoid is present was found to be inversely proportional to the value of Ki67 proliferation index. The results showed that Tc-99m-Tektrotyd SSRS is a sensitive method for diagnosing and staging patients with well-differentiated carcinoid tumors. However, in poorly differentiated tumors with high Ki67 proliferation index, additional analyses are necessary for precise staging.

Keywords : carcinoid tumor; somatostatin receptor scintigraphy; proliferation index Ki67

References

About the article

Received: 2014-02-28

Accepted: 2014-06-30

Published Online: 2014-11-26


Citation Information: Open Chemistry, ISSN (Online) 2391-5420, DOI: https://doi.org/10.1515/chem-2015-0042.

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© 2015 Marina Vlajković et al.. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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