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Volume 62, Issue 4

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Alkalimetric determination of hydrophobic pharmaceuticals using stabilized o/w emulsions

Ganna Shevchenko
  • Analytical Chemistry Department, Faculty of Chemistry, Taras Shevchenko Kyiv University, Volodymyrska Str. 64, Kyiv, 01033, Ukraine
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/ Sergey Kulichenko
  • Analytical Chemistry Department, Faculty of Chemistry, Taras Shevchenko Kyiv University, Volodymyrska Str. 64, Kyiv, 01033, Ukraine
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Published Online: 2008-06-30 | DOI: https://doi.org/10.2478/s11696-008-0038-7

Abstract

Protolytic properties of (+)-(S)-2-(6-methoxynaphthalen-2-yl)propanoic acid (naproxen), 2-(3-benzoylphenyl)propionic acid (ketoprofen), 4-chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid (furosemide), and N-(2,3-dimethylphenyl)anthranilic acid (mefenamic acid) in “oil-in-water” emulsions stabilized by surfactants were studied. The procedures for alkalimetric determination of naproxen, ketoprofen, furosemide, and mefenamic acid in emulsion media with indication of the equivalence point pH-metrically and with the use of indicators were proposed.

Keywords: pK; protolytic properties; hydrophobic pharmaceuticals; emulsion media; alkalimetric determination

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About the article

Published Online: 2008-06-30

Published in Print: 2008-08-01


Citation Information: Chemical Papers, Volume 62, Issue 4, Pages 435–439, ISSN (Online) 1336-9075, DOI: https://doi.org/10.2478/s11696-008-0038-7.

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© 2008 Institute of Chemistry, Slovak Academy of Sciences.

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