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Volume 66, Issue 1

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Mixed-ligand complexes of boric acid with organic biomolecules

Dursun Köse / Birgül Zümreoglu-Karan
Published Online: 2011-11-16 | DOI: https://doi.org/10.2478/s11696-011-0108-0

Abstract

Boric acid forms meta-stable complexes with biomolecules like amino and hydroxy acids and stable complexes with the diol group containing carbohydrates, vitamins, and nucleotides, yielding mono-chelate (1: 1 complex) or bis-chelate (1: 2 complex) structures with negatively charged tetrahedral borate anions. Here we report water-soluble, bio-available mixed-ligand boron adducts for potential nutritional and/or pharmaceutical applications. The complexes were prepared by complete esterification of boric acid with a number of acyclic- and cyclic hydroxy-functionalized biomolecules employing sodium as the counter ion. Structural and thermal properties of the complexes were investigated using chemical analysis, 11B NMR, FTIR, and TGA-DTA techniques. Complexes containing salicylic acid as one of the ligands displayed higher thermal and hydrolytic stabilities.

Keywords: boric acid complexes; boron adducts; borate esters; 11B NMR; mixed ligand complexes

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About the article

Published Online: 2011-11-16

Published in Print: 2012-01-01


Citation Information: Chemical Papers, Volume 66, Issue 1, Pages 54–60, ISSN (Online) 1336-9075, DOI: https://doi.org/10.2478/s11696-011-0108-0.

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