Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Chemical Papers

Online
ISSN
1336-9075
See all formats and pricing
More options …
Volume 68, Issue 2

Issues

Properties of poly(lactic acid-co-glycolic acid) film modified by blending with polyurethane

Guo-Quan Zhu / Fa-Gang Wang / Hong-Sheng Tan / Qiao-Chun Gao / Yu-Ying Liu
Published Online: 2013-10-30 | DOI: https://doi.org/10.2478/s11696-013-0438-1

Abstract

A number of poly(lactic acid-co-glycolic acid)/polyurethane (PLGA/PU) blend films with various PU mole contents were prepared by casting the polymer blend solution in chloroform. The surface morphologies of the PLGA/PU blend films were studied by scanning electron microscopy (SEM). The thermal, mechanical and chemical properties of the PLGA/PU blend films were investigated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), tensile tests and surface contact angle tests. The results revealed that the introduction of PU could markedly modify the properties of PLGA films.

Keywords: morphology; properties; PLGA/PU blend film; SEM; DSC; TGA

  • [1] Anderson, J. M., & Miller, K. M. (1984). Biomaterial biocompatibility and the macrophage. Biomaterials, 5, 5–10. DOI: 10.1016/0142-9612(84)90060-7. http://dx.doi.org/10.1016/0142-9612(84)90060-7CrossrefGoogle Scholar

  • [2] Angelova, N., & Hunkeler, D. (1999). Rationalizing the design of polymeric biomaterials. Trends in Biotechnology, 17, 409–421. DOI: 10.1016/s0167-7799(99)01356-6. http://dx.doi.org/10.1016/S0167-7799(99)01356-6CrossrefGoogle Scholar

  • [3] Bai, L. Q., Zhu, L. J., Min, S. J., Liu, L., Cai, Y. R., & Yao, J. M. (2008). Surface modification and properties of Bombyx mori silk fibroin films by antimicrobial peptide. Applied Surface Science, 254, 2988–2995. DOI: 10.1016/j.apsusc.2007.10.049. http://dx.doi.org/10.1016/j.apsusc.2007.10.049CrossrefGoogle Scholar

  • [4] Bittner, B., Witt, C., Mäder, K., & Kissel, T. (1999). Degradation and protein release properties of microspheres prepared from biodegradable poly(lactide-co-glycolide) and ABA triblock copolymers: influence of buffer media on polymer erosion and bovine serum albumin release. Journal of Controlled Release, 60, 297–309. DOI: 10.1016/s0168-3659(99)00085-1. http://dx.doi.org/10.1016/S0168-3659(99)00085-1CrossrefGoogle Scholar

  • [5] Blanco-Príeto, M. J., Besseghir, K., Zerbe, O., Andris, D., Orsolini, P., Heimgartner, F., Merkle, H. P., & Gander, B. (2000). In vitro and in vivo evaluation of a somatostatin analogue released from PLGA microspheres. Journal of Controlled Release, 67, 19–28. DOI: 10.1016/s0168-3659(99)00289-8. http://dx.doi.org/10.1016/S0168-3659(99)00289-8CrossrefWeb of ScienceGoogle Scholar

  • [6] Cleland, J. L., Johnson, O. L., Putney, S., & Jones, A. J. S. (1997). Recombinant human growth hormone poly(lactic-co-glycolic acid) microsphere formulation development. Advanced Drug Delivery Reviews, 28, 71–84. DOI: 10.1016/s0169-409x(97)00051-3. http://dx.doi.org/10.1016/S0169-409X(97)00051-3CrossrefGoogle Scholar

  • [7] Elbert, D. L., & Hubbell, J. A. (1998). Self-assembly and steric stabilization at heterogeneous, biological surfaces using adsorbing block copolymers. Chemistry and Biology, 5, 177–183. DOI: 10.1016/s1074-5521(98)90062-x. http://dx.doi.org/10.1016/S1074-5521(98)90062-XCrossrefGoogle Scholar

  • [8] Ganji, F., & Abdekhodaie, M. J. (2010). Chitosan-g-PLGA copolymer as a thermosensitive membrane. Carbohydrate Polymers, 80, 740–746. DOI: 10.1016/j.carbpol.2009.12.021. http://dx.doi.org/10.1016/j.carbpol.2009.12.021CrossrefWeb of ScienceGoogle Scholar

  • [9] Göpferich, A., Peter, S. J., Lucke, A., Lu, L., & Mikos, A. G. (1999). Modulation of marrow stromal cell function using poly(d,l-lactic acid)-block-poly(ethylene glycol)-monomethyl ether surfaces. Journal of Biomedical Materials Research Part A, 46, 390–398. DOI: 10.1002/(SICI)1097-4636(19990905)46:3〈390::AID-JBM12〉3.0.CO;2-N. http://dx.doi.org/10.1002/(SICI)1097-4636(19990905)46:3<390::AID-JBM12>3.0.CO;2-NCrossrefGoogle Scholar

  • [10] Harjunalanen, T., & Lahtinen, M. (2003). The effects of altered reaction conditions on the properties of anionic poly(urethane-urea) dispersions and films cast from the dispersions. European Polymer Journal, 39, 817–824. DOI: 10.1016/s0014-3057(02)00279-3. http://dx.doi.org/10.1016/S0014-3057(02)00279-3CrossrefGoogle Scholar

  • [11] Holzer, M., Vogel, V., Mäntele, W., Schwartz, D., Haase, W., & Langer, K. (2009). Physico-chemical characterisation of PLGA nanoparticles after freeze-drying and storage. European Journal of Pharmaceutics and Biopharmaceutics, 72, 428–437. DOI: 10.1016/j.ejpb.2009.02.002. http://dx.doi.org/10.1016/j.ejpb.2009.02.002CrossrefGoogle Scholar

  • [12] Houchin, M. L., Neuenswander, S. A., & Topp, E. M. (2007). Effect of excipients on PLGA film degradation and the stability of an incorporated peptide. Journal of Controlled Release, 117, 413–420. DOI: 10.1016/j.jconrel.2006.11.023. http://dx.doi.org/10.1016/j.jconrel.2006.11.023CrossrefWeb of ScienceGoogle Scholar

  • [13] Ignatius, A. A., & Claes, L. E. (1996). In vitro biocompatibility of bioresorbable polymers: poly(l, dl-lactide) and poly(l-lactide-co-glycolide). Biomaterials, 17, 831–839. DOI: 10.1016/0142-9612(96)81421-9. http://dx.doi.org/10.1016/0142-9612(96)81421-9CrossrefGoogle Scholar

  • [14] Jain, R. A. (2000). The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials, 21, 2475–2490. DOI: 10.1016/s0142-9612(00)00115-0. http://dx.doi.org/10.1016/S0142-9612(00)00115-0CrossrefGoogle Scholar

  • [15] Jeong, J. H., Lim, D. W., Han, D. K., & Park, T. G. (2000). Synthesis, characterization and protein adsorption behaviors of PLGA/PEG di-block co-polymer blend films. Colloids and Surfaces B: Biointerfaces, 18, 371–379. DOI: 10.1016/s0927-7765(99)00162-9. http://dx.doi.org/10.1016/S0927-7765(99)00162-9CrossrefGoogle Scholar

  • [16] Kondo, T., Sawatari, C., Manley, R. S. J., & Gray, D. G. (1994). Characterization of hydrogen bonding in cellulose-synthetic polymer blend systems with regioselectively sub stituted methylcellulose. Macromolecules, 27, 210–215. DOI: 10.1021/ma00079a031. http://dx.doi.org/10.1021/ma00079a031CrossrefGoogle Scholar

  • [17] Langer, R. (1995). 1994 Whitaker lecture: Polymers for drug delivery and tissue engineering. Annals of Biomedical Engineering, 23, 101–111. DOI: 10.1007/bf02368317. http://dx.doi.org/10.1007/BF02368317Web of ScienceCrossrefGoogle Scholar

  • [18] Lio, K., Minoura, N., & Nagura, M. (1995). Swelling characteristics of a blend hydrogel made of poly(allylbiguanido-co-allylamine) and poly(vinyl alcohol). Polymer, 36, 2579–2583. DOI: 10.1016/0032-3861(95)91204-k. http://dx.doi.org/10.1016/0032-3861(95)91204-KCrossrefGoogle Scholar

  • [19] Loo, S. C. J., Ooi, C. P., & Boey, Y. C. F. (2004). Radiation effects on poly(lactide-co-glycolide) (PLGA) and poly(l-lactide) (PLLA). Polymer Degradation and Stability, 83, 259–265. DOI: 10.1016/s0141-3910(03)00271-4. http://dx.doi.org/10.1016/S0141-3910(03)00271-4CrossrefGoogle Scholar

  • [20] Loo, S. C. J., Ooi, C. P., Wee, S. H. E., & Boey, Y. C. F. (2005). Effect of isothermal annealing on the hydrolytic degradation rate of poly(lactide-co-glycolide) (PLGA). Biomaterials, 26, 2827–2833. DOI: 10.1016/j.biomaterials.2004.08.031. http://dx.doi.org/10.1016/j.biomaterials.2004.05.001CrossrefGoogle Scholar

  • [21] Murakami, H., Kobayashi, M., Takeuchi, H., & Kawashima, Y. (2000). Utilization of poly(dl-lactide-co-glycolide) nanoparticles for preparation of mini-depot tablets by direct compression. Journal of Controlled Release, 67, 29–36. DOI: 10.1016/s0168-3659(99)00288-6. http://dx.doi.org/10.1016/S0168-3659(99)00288-6CrossrefGoogle Scholar

  • [22] Nishio, Y., & Manley, R. S. J. (1988). Cellulose-poly(vinyl alcohol) blends prepared from solutions in N,N-dimethylacetamide-lithium chloride. Macromolecules, 21, 1270–1277. DOI: 10.1021/ma00183a016. http://dx.doi.org/10.1021/ma00183a016CrossrefGoogle Scholar

  • [23] Park, J. S., Park, J. W., & Ruckenstein, E. (2001). Thermal and dynamic mechanical analysis of PVA/MC blend hydogels. Polymer, 42, 4271–4280. DOI: 10.1016/s0032-3861(00)00768-0. http://dx.doi.org/10.1016/S0032-3861(00)00768-0CrossrefGoogle Scholar

  • [24] Park, B. J., Seo, H. J., Kim, J., Kim, H. L., Kim, J. K., Choi, J. B., Han, I., Hyun, S. O., Chung, K. H., & Park, J. C. (2010). Cellular responses of vascular endothelial cells on surface modified polyurethane films grafted electospun PLGA fiber with microwave-induced plasma at atmospheric pressure. Surface & Coatings Technology, 205, s222–s226. DOI: 10.1016/j.surfcoat.2010.07.087. http://dx.doi.org/10.1016/j.surfcoat.2010.07.087CrossrefWeb of ScienceGoogle Scholar

  • [25] Peppas, N. A., Huang, Y., Torres-Lugo, M., Ward, J. H., & Zhang, J. (2000). Physicochemical foundations and structural design of hydrogels in medicine and biology. Annual Review of Biomedical Engineering, 2, 9–29. DOI: 10.1146/annurev.bioeng.2.1.9. http://dx.doi.org/10.1146/annurev.bioeng.2.1.9CrossrefGoogle Scholar

  • [26] Rowlands, A. S., Lim, S. A., Martin, D., & Cooper-White, J. J. (2007). Polyurethane/poly(lactic-co-glycolic) acid composite scaffolds fabricated by thermally induced phase separation. Biomaterials, 28, 2109–2121. DOI: 10.1016/j.biomaterials.2006.12.032. http://dx.doi.org/10.1016/j.biomaterials.2006.12.032Web of ScienceCrossrefGoogle Scholar

  • [27] Sawatari, C., & Kondo, T. (1999). Interchain hydrogen bonds in blend films of poly(vinyl alcohol) and its derivatives with poly(ethylene oxide). Macromolecules, 32, 1949–1955. DOI: 10.1021/ma980900o. http://dx.doi.org/10.1021/ma980900oCrossrefGoogle Scholar

  • [28] Schliecker, G., Schmidt, C., Fuchs, S., Wombacher, R., & Kissel, T. (2003). Hydrolytic degradation of poly(lactide-co-glycolide) films: effect of oligomers on degradation rate and crystallinity. International Journal of Pharmaceutics, 266, 39–49. DOI: 10.1016/s0378-5173(03)00379-x. http://dx.doi.org/10.1016/S0378-5173(03)00379-XCrossrefGoogle Scholar

  • [29] Steele, T. W. J., Huang, C. L., Widjaja, E., Boey, F. Y. C., Loo, J. S. C., & Venkatraman, S. S. (2011). The effect of polyethylene glycol structure on paclitaxel drug release and mechanical properties of PLGA thin films. Acta Biomaterialia, 7, 1973–1983. DOI: 10.1016/j.actbio.2011.02.002. http://dx.doi.org/10.1016/j.actbio.2011.02.002CrossrefGoogle Scholar

  • [30] Stolnik, S., Dunn, S. E., Garnett, M. C., Davies, M. C., Coombes, A. G. A., Taylor, D. C., Irving, M. P., Purkiss, S. C., Tadros, T. F., Davis, S. S., & Illum, L. (1994). Surface modification of poly (lactide-co-glycolide) nanospheres by biodegradable poly(lactide)-poly(ethylene glycol) copolymers. Pharmaceutical Research, 11, 1800–1808. DOI: 10.1023 /a:1018931820564. http://dx.doi.org/10.1023/A:1018931820564CrossrefGoogle Scholar

  • [31] Sung, C. S. P., Smith, T. W., & Sung, N. H. (1980). Properties of segmented polyether poly(urethaneureas) based of 2,4-toluene diisocyanate. 2. Infrared and mechanical studies. Macromolecules, 13, 117–121. DOI: 10.1021/ma60073a023. http://dx.doi.org/10.1021/ma60073a023CrossrefGoogle Scholar

  • [32] Tanaka, H., Suzuki, Y., & Yoshino, F. (1999). Synthesis and coating application of waterborne fluoroacrylic-polyurethane composite dispersions. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 153, 597–601. DOI: 10.1016/s0927-7757(98)00482-8. http://dx.doi.org/10.1016/S0927-7757(98)00482-8CrossrefGoogle Scholar

  • [33] Thanki, P. N., Dellacherie, E., & Six, J. L. (2006). Surface characteristics of PLA and PLGA films. Applied Surface Science, 253, 2758–2764. DOI: 10.1016/j.apsusc.2006.05.047. http://dx.doi.org/10.1016/j.apsusc.2006.05.047CrossrefGoogle Scholar

  • [34] Vey, E., Roger, C., Meehan, L., Booth, J., Claybourn, M., Miller, A. F., & Saiani, A. (2008). Degradation mechanism of poly(lactic-co-glycolic) acid block copolymer cast films in phosphate buffer solution. Polymer Degradation and Stability, 93, 1869–1876. DOI: 10.1016/j.polymdegradstab.2008.07.018. http://dx.doi.org/10.1016/j.polymdegradstab.2008.07.018CrossrefGoogle Scholar

  • [35] Yoon, S. D., Park, M. H., & Byun, H. S. (2012). Mechanical and water barrier properties of starch/PVA composite films by adding nano-sized poly(methyl methacrylate-coacrylamide) particles. Carbohydrate Polymers, 87, 676–686. DOI: 10.1016/j.carbpol.2011.08.046. http://dx.doi.org/10.1016/j.carbpol.2011.08.046CrossrefGoogle Scholar

  • [36] Zhu, G. Q., Wang, F. G., Gao, Q. C., Li, G. C., & Wang, P. (2011). Properties of poly(γ-benzyl l-glutamate) membrane modified by polyurethane containing carboxyl group. Chemical Papers, 65, 483–489. DOI: 10.2478/s11696-011-0032-3. http://dx.doi.org/10.2478/s11696-011-0032-3CrossrefGoogle Scholar

  • [37] Zou, M. X., Wang, S. J., Zhang, Z. C., & Ge, X. W. (2005). Preparation and characterization of polysiloxane-poly(butyl acrylate-styrene) composite latices and their film properties. European Polymer Journal, 41, 2602–2613. DOI: 10.1016/j.eurpolymj.2005.05.038. http://dx.doi.org/10.1016/j.eurpolymj.2005.05.038CrossrefGoogle Scholar

About the article

Published Online: 2013-10-30

Published in Print: 2014-02-01


Citation Information: Chemical Papers, Volume 68, Issue 2, Pages 246–252, ISSN (Online) 1336-9075, DOI: https://doi.org/10.2478/s11696-013-0438-1.

Export Citation

© 2013 Institute of Chemistry, Slovak Academy of Sciences.

Comments (0)

Please log in or register to comment.
Log in