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Volume 69, Issue 4

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Eco-friendly conjugate hydrocyanation of α-cyanoacrylates using potassium hexacyanoferrate(II) as cyanating reagent

Yu-Peng Zhang
  • College of Chemistry and Chemical Engineering Northwest Normal University, Lanzhou, Gansu 730070, China
  • Other articles by this author:
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/ Xiao-Chun Hu
  • Editorial Department of the University Journal, Northwest Normal University, Lanzhou, Gansu 730070, China
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/ Zheng Li
  • Corresponding author
  • College of Chemistry and Chemical Engineering Northwest Normal University, Lanzhou, Gansu 730070, China
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Published Online: 2015-03-03 | DOI: https://doi.org/10.1515/chempap-2015-0055

Abstract

The conjugate hydrocyanation of α-cyanoacrylates through chemoselective 1,4-addition to synthesise α,β-dicyanopropanoates by one-pot two-step procedure using potassium hexacyanoferrate(II) as an eco-friendly cyanide source, benzoyl chloride as a promoter and potassium carbonate as a catalyst is described. The advantages of this protocol are use of a non-toxic, non-volatile and inexpensive cyanating reagent, high product yields and simple working procedure

This article offers supplementary material which is provided at the end of the article.

Keywords: conjugate hydrocyanation; α-cyanoacrylate; “green chemistry”; potassium hexacyanoferrate( II)

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About the article

Received: 2014-04-30

Revised: 2014-08-27

Accepted: 2014-08-28

Published Online: 2015-03-03

Published in Print: 2015-04-01


Citation Information: Chemical Papers, Volume 69, Issue 4, Pages 596–603, ISSN (Online) 1336-9075, ISSN (Print) 0366-6352, DOI: https://doi.org/10.1515/chempap-2015-0055.

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