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Acta Chirurgica Latviensis

The Journal of Riga Stradins University; Latvian Association of Surgeons; Latvian Association of Paediatric Surgeons

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The role of biopsy in differential diagnostics of kidney graft pathology

Vadims Suhorukovs
  • Latvian Transplantation Centre, Pauls Stradins Clinical University Hospital, Riga, Latvia
/ Tatjana Tihomirova
  • Latvian Transplantation Centre, Pauls Stradins Clinical University Hospital, Riga, Latvia
Published Online: 2010-08-18 | DOI: https://doi.org/10.2478/v10163-010-0004-7

The role of biopsy in differential diagnostics of kidney graft pathology

Introduction. Different pathological changes of kidney transplants have similar symptoms, thus differential diagnostic is sometime difficult. The important information that may help to set correct diagnose can be obtained from the kidney transplant biopsy followed by pathohistological investigation.

Aim of the study. The aim of this study is to demonstrate the role of biopsy in differential diagnostics of kidney graft pathology.

Materials and methods. 109 kidney graft biopsies were performed at the Latvian Transplantation Centre in 2007: 20 were protocol biopsies and 89 were performed according to indications (graft dysfunction). All biopsies were performed under USS control followed by pathohistological investigations of the material obtained. Morphological changes were evaluated accordingly to the Banff 97 classification.

Results. The morphological findings were as follows: borderline changes - 8 cases (7.34%); acute cellular rejection - 80 cases (73.4%); acute humoral rejection - 1 case (0,92%); hronic graft nephropathy - 27 cases (24.8%); tubolointersticial nephritis - 36 cases (33%); apostematous nephritis - 1 case (0.92%). We observed mild hematuria in only 2 patients after biopsy which stopped spontaneously in a few days.

Conclusions. Kidney graft biopsy followed by pathohistological investigation of the material obtained is a precise and sensitive method in the diagnostic process of pathological changes of the graft with a small rate of complication.

Keywords: kidney transplantation; kidney graft biopsy; kidney graft pathology

  • Bonsib SM, Reznicek MJ, Wright FH. Renal medulla in the diagnosis of acute cellular rejection // Transplantation, 1989; 48:690-692 [PubMed]

  • Colvin RB, Cohen AH, Saiontz C, et al. Evaluation of pathologiccriteria for acute renal allograft rejection reproducibility, sensitivity, and clinical correlation // J Am Soc Nephrol, 1997; 8:1930-1941 [PubMed]

  • Fonseka LE, Shapiro R, Randhawa PS., Occurrence of urinary tracīt infection in patients with renal allograft biopsies showing neutrophilic tubulitis // Mod Pathol, 2003; 16:281-285

  • Hirsch HH, Knowles W, Dickenmann M, et al. Prospective study of polyomavirus type BK replication and nephropathy in renal transplant recipients // N Eng J Med, 2002; 347:488-496

  • Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology // Kidney Int, 1999; 55:713-723 [PubMed]

  • Sorof JM, Vartanian RK, Olson JL, et al. Histopathologicalconcordance of paired renal allograft biopsy: Effect on the diagnosisand management of acute rejection // Transplantation, 1995; 60:1215-1219

  • Sulikowski T, Tejchman K, Domański L, et al. Histopathologic evaluation of pretransplant biopsy as a factor influencing graft function after kidney transplantation: a 1-year observation // Transplant Proc, 2007; 39:943-7 [Web of Science]

About the article

Published Online: 2010-08-18

Published in Print: 2009-01-01

Citation Information: Acta Chirurgica Latviensis, ISSN (Print) 1407-981X, DOI: https://doi.org/10.2478/v10163-010-0004-7. Export Citation

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