Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Acta Chirurgica Latviensis

The Journal of Riga Stradins University; Latvian Association of Surgeons; Latvian Association of Paediatric Surgeons

2 Issues per year

Open Access
See all formats and pricing
More options …

Biliary Cystic Tumours with Mesenchymal Stroma

Andrejs Vanags / Maris Pavars / Peteris Prieditis / Ilze Strumfa / Arvids Irmejs / Janis Gardovskis
Published Online: 2010-08-18 | DOI: https://doi.org/10.2478/v10163-010-0019-0

Biliary Cystic Tumours with Mesenchymal Stroma

Biliary cystadenoma and cystadenocarcinoma are rare cystic liver tumours arising from the bile ducts proximal to the hilum of the liver. The tumours have unique structure with ovarian-type mesenchymal stroma, leading to challenging considerations about their pathogenesis. The differential diagnosis is wide and further complicated by the lack of awareness about these neoplastic processes due to the rarity of the disease. Radical surgical treatment can be recommended whenever possible as it can result in prolonged survival.

Keywords: biliary cystadenoma; biliary cystadenocarcinoma; mesenchymal stroma

  • Bardin RL, Trupiano JK, Howerton RM, Geisinger KR. Oncocytic biliary cystadenocarcinoma: a case report and review of the literature // Arch Pathol Lab Med, 2004; 128(2):25-28Google Scholar

  • Davies W, Chow M, Nagorney D. Extrahepatic biliary cystadenomas and cystadenocarcinoma // Ann Surg, 1995; 222(5):619-625CrossrefPubMedGoogle Scholar

  • D'Errico A, Deleonardi G, Fiorentino M, Scoazek JY, Grigioni WF. Diagnostic implications of albumin messenger RNA detection and cytokeratin pattern in benign hepatic lesions and biliary cystadenocarcinoma // Diagn Mol Pathol, 1998; 76:289-294Google Scholar

  • Hamilton SR, Aaltonen LA (eds.) Pathology and genetics. Tumours of the digestive system. Lyon: IARC Press; 2000; 1-314Google Scholar

  • Hanazaki K, Yoshizawa K, Mori H. Hepatic arterial infusion chemotherapy of cisplatin for biliary cystadenocarcinoma // Hepatogastroenterology, 1999; 46(25):462-464PubMedGoogle Scholar

  • Ishak KG, Willis GW, Cummins SD, Bullock AA. Biliary cystadenoma and cystadenocarcinoma: report of 14 cases and review of the literature // Cancer, 1977; 38:322-338CrossrefGoogle Scholar

  • Ishibashi Y, Ojima H, Hiraoka N, Sano T, Kosuge T, Kanai Y. Invasive biliary cystic tumour without ovarian-like stroma // Pathol Int, 2007; 57(12): 794-798Web of ScienceCrossrefPubMedGoogle Scholar

  • Iyama S, Takahashi Y, Shintani N, Fujikawa K, Ohkubo S, Sato Y, Sato T, Sato Y, Ohnuma K, Niitsu Y. [A case of recurrent biliary cystadenocarcinoma successfully treated with 5FU/CDDP systemic chemotherapy] // Nippon Shokakibyo Gakkai Zasshi, 2006; 103(10):1163-1168. [Pubmed abstract PMID 17023760]Google Scholar

  • Jan YY, Chen MF, Chen TJ. [Cholangiocarcinoma with mucobilia] // J Formos Med Assoc, 1994; 93, Suppl 3: S149-155. [Pubmed abstract PMID7606173]Google Scholar

  • Karahan OI, Kahriman G, Soyuer I, Ok E. Hepatic von Meyenburg complex simulating biliary cystadenocarcinoma // Clin Imaging, 2007; 31(1): 50-53Web of ScienceCrossrefGoogle Scholar

  • Kitajima Y, Okayama Y, Hirai M, Hayashi K, Imai H, Okamoto T, Aoki S, Akita S, Gotoh K, Ohara H, Nomura T, Joh T, Yokoyama Y, Itoh M. Intracystic hemorhage of a simple liver cyst mimicking a biliary cystadenocarcinoma. J Gastroenterol, 2003; 38(2):190-193CrossrefGoogle Scholar

  • Koffron A, Rao S, Ferrario M, Abecassis M. Intrahepatic biliary cystadenoma: role of cyst fluid analysis and surgical management in the laparoscopic era // Surgery, 2004; 136:926-936Google Scholar

  • Kubota E, Katsumi K, Iida M, Kishimoto A, Ban Y, Nakata K, Takahashi N, Kobayashi K, Andoh K, Takamatsu S, Joh T. Biliary cystadenocarcinoma, followed up as benign cystadenoma for 10 years // J Gastroenterol, 2003; 38(3):278-282PubMedCrossrefGoogle Scholar

  • Madariaga JR, Iwatsuki S, Starzi TE, Todo S, Selby R, Zetti G. Hepatic resection for cystic lesions of the liver // Ann Surg, 1993; 218(5):610-614PubMedCrossrefGoogle Scholar

  • Manouras A, Markogiannis H, Lagoudianakis E, Katergiannakis V. Biliary cystadenoma with mesenchymal stroma: report of the case and review of the literature // World J Gastroenterol, 2006; 12(37):6062-6069Web of SciencePubMedGoogle Scholar

  • Mortele KJ, Ros PR. Cystic focal liver lesions in the adult: differential CT and MR imaging features // RadioGraphics 2001; 21:895-910CrossrefGoogle Scholar

  • Poggio P, Buonocore M. Cystic tumours of the liver: A practical approach // World J Gastroenterol, 2008; 14(23):3616-3620CrossrefPubMedWeb of ScienceGoogle Scholar

  • Pojchamarnwiputh S, Na Chiangmai W, Chotirosniramit A, Lertprasertsuke N. Computed tomography of biliary cystadenoma and biliary cystadenocarcinoma // Singapore Med J, 2008; 49(5):392-396PubMedGoogle Scholar

  • Proietti S, Abdelmoumene A, Genevay M, Denys A. Ecchinococcal Cyst // RadioGraphics, 2004; 24: 861-865CrossrefGoogle Scholar

  • Rullier A, Le Bail B, Fawaz R, Blanc JF, Saric J, Bioulac-Sage P. Cytokeratin 7 and 20 expression in cholangiocarcinomas varies along the biliary tree but still differs from that in colorectal carcinoma metastasis // Am J Surg Pathol, 2000; 24(6): 870-876CrossrefGoogle Scholar

  • Shrikhande S, Kleef J, Adyanthaya K, Zimmermann A, Shrikhande V. Management of hepatobiliary cystadenocarcinoma // Dig Surg, 2003; 20:60-63CrossrefPubMedGoogle Scholar

  • Sudo Y, Harada K, Tsuneyama K, Katayanagi K, Zen Y, Nakanuma Y. Oncocytic biliary cystadenocarcinoma is a form of intraductal papillary neoplasm of the liver // Mod Pathol, 2001; 14(12):1304-1309PubMedCrossrefGoogle Scholar

  • Thomas KT, Welch D, Trueblood A, Sulur P, Wise P, Gorden L, Chari RS, Wright JK, Washington K, Pinson CW. Effective treatment of biliary cystadenoma // Ann Surg, 2005; 241:769-775Google Scholar

  • Vanags A, Pavars M, Prieditis P, Strumfa I, Irmejs A, Gardovskis J. Biliary cystadenocarcinoma: a case study of a rare tumour // Acta Chirurgica Latviensis, 2008; 8:90-93.Google Scholar

  • Wheeler DA, Edmondson HA. Cystadenoma with mesenchymal stroma (CMS) in the liver and bile ducts // Cancer, 1985; 56(6):1434-1435PubMedCrossrefGoogle Scholar

  • Woods G. Biliary cystadenoma: case report of hepatic malignancy originating in benign cystadenoma // Cancer, 1981; 47:2936-2940CrossrefPubMedGoogle Scholar

  • Yu FC, Chen JH, Yang KC, Wu CC, Chou YY. Hepatobiliary cystadenoma: a report of two cases // J Gastrointestin Liver Dis, 2008:17(2):203-206PubMedGoogle Scholar

  • Zamboni G, Scarpa A, Bogina G, Iacono C, Bassi C, Talamini, Sessa F, Capella C, Solcia E, Rickaert F, Mariuzzi GM, Klopel G. Mucinous cystic tumors of the pancreas: clinicopathologic features, prognosis, and relationship to other mucinous cystic tumors // Am J Surg Pathol, 1999; 23:410-422CrossrefGoogle Scholar

  • Zen Y, Fujii T, Itatsu K, Nakamura K, Konishi F, Masuda S, Mitsui T, Asada Y, Miura S, Miyayama S, Uehara T, Katsuyama T, Ohta T, Minato H, Nakanuma Y. Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct // Mod Pathol, 2006; 19:1243-1254CrossrefPubMedGoogle Scholar

  • Zhang M, Yu J, Yan S, Zheng SS. Cystadenocarcinoma of the liver: a case report // Hepatobiliary Pancreat Dis Int, 2005; 4(3):464-467Google Scholar

  • Zhou JP, Dong M, Zhang Y, Kong FM, Guo KJ, Tian YL. Giant mucinous biliary cystadenoma: a case report // Hepatobiliary Pancreat Dis Int, 2007; 6(1):101-103Google Scholar

About the article

Published Online: 2010-08-18

Published in Print: 2009-01-01

Citation Information: Acta Chirurgica Latviensis, Volume 9, Issue 1, Pages 95–99, ISSN (Print) 1407-981X, DOI: https://doi.org/10.2478/v10163-010-0019-0.

Export Citation

This content is open access.

Comments (0)

Please log in or register to comment.
Log in