Endocrine Disruptors in the Environment (IUPAC Technical Report)
by J. Lintelmann, A. Katayama, N. Kurihara, L. Shore, and A. Wenzel
Pure and Applied Chemistry,
Vol. 75, No. 5, pp. 631–681 (2003)
Many chemical substances of natural or anthropogenic origin are suspected or known to be endocrine disruptors, which can influence the endocrine system of life. This observation has led to an increased interest on the part of the public and the media, as well as to a steep rise in research activities within the scientific community. New papers and results are presented so quickly that it is impossible to give a complete review of this emerging research field. Therefore, this paper tries to provide insight into several topics that encompass the great scope of endocrine disruptors in the environment.
The paper explains some parts of the endocrine systems of mammalians and non-mammalians in order to provide general biochemical and biological background information. Important mechanisms of endocrine disruption, such as interactions with hormone receptors, are described. Strategies for testing anthropogenic chemicals on various organisms are critically reviewed with respect to their problems and gaps. The main emphasis of the paper involves chemical substances that are suspected or known to be endocrine disruptors. Physicochemical data, such as water solubility, as well as information about their use and/or function, are reviewed and compared to provide a clearer picture of their behavior in the environment. The paper also describes the main routes of exposure for most chemicals and provides data related to concentrations in the environment (soil/sediment, water).
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About the article
Published Online: 2009-09-01
Published in Print: 2003-07-01