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Review on analgesic effect of co-administrated ibuprofen and caffeine

Andrzej Polski
  • Corresponding author
  • Department of Applied Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Regina Kasperek
  • Department of Applied Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Karolina Sobotka-Polska / Ewa Poleszak
  • Department of Applied Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2014-05-30 | DOI: https://doi.org/10.2478/cipms-2014-0003


Pain is a symptom of many diseases and significantly affects the quality of life, so researchers are constantly seeking new substances to be used as analgesics. Other, easier way is to combine already known drugs which cause synergistic effects greater than additive, so that probability of drug-specific side effects can be reduced. Researchers showed that caffeine can be an effective analgesic adjuvant enhancing antinociceptive effect of ibuprofen in animals and humans. By using modern drug technology methods tablets containing well-soluble ibuprofen salt and caffeine can be easily prepared. Thanks to that combination, the therapeutic dose of ibuprofen can be lowered and the side effects may be reduced.

Keywords: analgesic; caffeine; ibuprofen; tablets


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About the article

Received: 2013-12-06

Accepted: 2014-02-14

Published Online: 2014-05-30

Published in Print: 2014-06-01

Citation Information: Current Issues in Pharmacy and Medical Sciences, Volume 27, Issue 1, Pages 10–13, ISSN (Online) 2300-6676, ISSN (Print) 2084-980X, DOI: https://doi.org/10.2478/cipms-2014-0003.

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© 2014. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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