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Current Issues in Pharmacy and Medical Sciences

Formerly Annales UMCS Sectio DDD Pharmacia

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CiteScore 2016: 0.19

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2300-6676
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Immunomodulatory and anti-inflammatory properties of macrolides

Magdalena Bulska
  • Corresponding author
  • Chair and Department of Biopharmacy, Faculty of Pharmacy, Medical Univeristy of Lodz, Muszynskiego 1, 90-151 Lodz, Poland
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Daria Orszulak-Michalak
  • Chair and Department of Biopharmacy, Faculty of Pharmacy, Medical Univeristy of Lodz, Muszynskiego 1, 90-151 Lodz, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2014-05-30 | DOI: https://doi.org/10.2478/cipms-2014-0015

Abstract

Macrolides are a group of antibiotics whose activity is ascribable to the presence of the macrolide ring, to which one or more deoxy sugars may be attached. Two properties are inherent in this group of antibiotics, the immunomodulatory and the anti-inflammatory actions, ensuring great efficacy in a wide spectrum of infections. Macrolides demonstrate several immunomodulatory activities both in vitro and in vivo. They can down-regulate prolonged inflammation, increase mucus clearance, prevent the formation of bacterial biofilm and either enhance or reduce activation of the immune system. According to given properties and exceptional effects on bacterial phatogens, the macrolide antimicrobial agents have been found to serve a unique role in the management of chronic airway disorders, including diffuse panbronchiolitis, cystic fibrosis and chronic obstructive pulmonary disease. Use of macrolides can result in clinical improvement in patients with severe, chronic inflammatory airway diseases, improving their spirometry indicators, gas exchange and overall quality of life.

Keywords: antibiotics; immunomodulation; inflammation; macrolides

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About the article

Received: 2014-02-03

Accepted: 2014-03-25

Published Online: 2014-05-30

Published in Print: 2014-06-01


Citation Information: Current Issues in Pharmacy and Medical Sciences, Volume 27, Issue 1, Pages 61–64, ISSN (Online) 2300-6676, ISSN (Print) 2084-980X, DOI: https://doi.org/10.2478/cipms-2014-0015.

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© 2014. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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