The technical successes in radio navigation and the availability of nu-merical algorithms have promoted the implementation of GPS-technology to atmo-spheric sciences. The tomographical contribution of Global Satellite Navigation Sys-tems (GNSS) is possible due to the methods of high precision detection of tropospheric delays of navigation signals from satellites to receivers. The principal specific char-acter in initial constraints, data collection and assimilation methods, the obtaining of final numerical results and their interpretation make the continuation of the success story for GPS-tomography very challenging. The authors use numerical simulation as the most time- and cost-efficient way to study different processes related to tro-pospheric water vapor tomography. This paper tends to give a short overview about some known methods in GPS-tomography for detection, monitoring and modeling of the tropospheric water vapor. The possible mathematical approach to the construc-tion of virtual network of ground-based sensors (GPS-receivers) for a real geographical location and discretization of the troposphere, also some aspects of raw data filtering and analysis are described. Output of tomographical modelling of the troposphere can be used to improve the results of large-scale numerical weather prediction models and also real-time navigation. The questions of voxel geometry and methods of data processing are supposed to be the key questions in constructing an effective network of GPS-receivers for water vapor tomography.