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Cellular and Molecular Biology Letters

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Volume 11, Issue 4


Endoplasmic reticulum stress and apoptosis

Jitka Faitova
  • Department of Pathology and Experimental Oncology, Masaryk Memorial Cancer Institute, Zluty Kopec 7, 656 53, Brno, Czech Republic
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/ Daniel Krekac
  • Department of Pathology and Experimental Oncology, Masaryk Memorial Cancer Institute, Zluty Kopec 7, 656 53, Brno, Czech Republic
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/ Roman Hrstka
  • Department of Pathology and Experimental Oncology, Masaryk Memorial Cancer Institute, Zluty Kopec 7, 656 53, Brno, Czech Republic
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/ Borivoj Vojtesek
  • Department of Pathology and Experimental Oncology, Masaryk Memorial Cancer Institute, Zluty Kopec 7, 656 53, Brno, Czech Republic
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Published Online: 2006-09-05 | DOI: https://doi.org/10.2478/s11658-006-0040-4


Cell death is an essential event in normal life and development, as well as in the pathophysiological processes that lead to disease. It has become clear that each of the main cellular organelles can participate in cell death signalling pathways, and recent advances have highlighted the importance of the endoplasmic reticulum (ER) in cell death processes. In cells, the ER functions as the organelle where proteins mature, and as such, is very responsive to extracellular-intracellular changes of environment. This short overview focuses on the known pathways of programmed cell death triggering from or involving the ER.

Keywords: Endoplasmic reticulum; Apoptosis; p53; Scotin

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About the article

Published Online: 2006-09-05

Published in Print: 2006-12-01

Citation Information: Cellular and Molecular Biology Letters, Volume 11, Issue 4, Pages 488–505, ISSN (Online) 1689-1392, DOI: https://doi.org/10.2478/s11658-006-0040-4.

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© 2006 University of Wrocław, Poland. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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