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Natriuretic peptides in cardiovascular diseases

1Department of Anaesthesiology and Intensive Care Unit, Boleslaw Szarecki, University Hospital No. 5 in Łódź, Medical University in Łódź, Łódź, Poland

2Department Cardiology, 1st Chair of Cardiology and Cardiac Surgery, University Hospital No. 3 in Łódź, Medical University in Łódź, Łódź, Poland

3Department of Health Protection Policy, Medical University of Łódź, Łódź, Poland

42nd Department of Family Medicine, University Hospital No. 2 in Łódź, Medical University in Łódź, Łódź, Poland

5Department of Cardiology, Medical University of Łódź, Sterlinga 1/3, 91-425, Łódź, Poland

© 2007 University of Wrocław, Poland. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. (CC BY-NC-ND 3.0)

Citation Information: Cellular and Molecular Biology Letters. Volume 13, Issue 2, Pages 155–181, ISSN (Online) 1689-1392, DOI: 10.2478/s11658-007-0046-6, April 2008

Publication History

Published Online:


The natriuretic peptide family comprises atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), dendroaspis natriuretic peptide (DNP), and urodilatin. The activities of natriuretic peptides and endothelins are strictly associated with each other. ANP and BNP inhibit endothelin-1 (ET-1) production. ET-1 stimulates natriuretic peptide synthesis. All natriuretic peptides are synthesized from polypeptide precursors. Changes in natriuretic peptides and endothelin release were observed in many cardiovascular diseases: e.g. chronic heart failure, left ventricular dysfunction and coronary artery disease.

Keywords: Atrial natriuretic peptide; Brain natriuretic peptide; C-type natriuretic peptide; Dendroaspis natriuretic peptide; Urodilatin; Endothelin-1

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