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Cellular and Molecular Biology Letters

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Volume 14, Issue 2 (Jun 2009)

Perturbation of the lipid phase of a membrane is not involved in the modulation of MRP1 transport activity by flavonoids

Olga Wesołowska / Andrzej Hendrich / Barbara Łania-Pietrzak / Jerzy Wiśniewski / Joseph Molnar / Imre Ocsovszki / Krystyna Michalak
Published Online: 2009-03-13 | DOI: https://doi.org/10.2478/s11658-008-0044-3

Abstract

The expression of transmembrane transporter multidrug resistance-associated protein 1 (MRP1) confers the multidrug-resistant phenotype (MDR) on cancer cells. Since the activity of the other MDR transporter, P-glycoprotein, is sensitive to membrane perturbation, we aimed to check whether the changes in lipid bilayer properties induced by flavones (apigenin, acacetin) and flavonols (morin, myricetin) were related to their MRP1 inhibitory activity. All the flavonoids inhibited the efflux of MRP1 fluorescent substrate from human erythrocytes and breast cancer cells. Morin was also found to stimulate the ATPase activity of erythrocyte ghosts. All flavonoids intercalated into phosphatidylcholine bilayers as judged by differential scanning calorimetry and fluorescence spectroscopy with the use of two carbocyanine dyes. The model of an intramembrane localization for flavones and flavonols was proposed. No clear relationship was found between the membrane-perturbing activity of flavonoids and their potency to inhibit MRP1. We concluded that mechanisms other than perturbation of the lipid phase of membranes were responsible for inhibition of MRP1 by the flavonoids.

Keywords: Flavonoids; Multidrug resistance-associated protein 1 (MRP1); Lipid bilayer; Carbocyanine dyes

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Published Online: 2009-03-13

Published in Print: 2009-06-01


Citation Information: Cellular and Molecular Biology Letters, ISSN (Online) 1689-1392, DOI: https://doi.org/10.2478/s11658-008-0044-3.

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Chemistry and Physics of Lipids, 2014, Volume 178, Page 77
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Olga Wesołowska, Justyna Gąsiorowska, Joanna Petrus, Bogusława Czarnik-Matusewicz, and Krystyna Michalak
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2014, Volume 1838, Number 1, Page 173
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Yuri A. Kim, Yury S. Tarahovsky, Elena A. Yagolnik, Svetlana M. Kuznetsova, and Eugeny N. Muzafarov
Biochemical and Biophysical Research Communications, 2013, Volume 431, Number 4, Page 680
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Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013, Volume 1828, Number 2, Page 518
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Michal Ciolkowski, Monika Rozanek, Michal Szewczyk, Barbara Klajnert, and Maria Bryszewska
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011, Volume 1808, Number 11, Page 2714
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Maksim Ionov, Ilnora Tukfatullina, Bakhtiyar Salakhutdinov, Nina Baram, Maria Bryszewska, and Takhir Aripov
Cellular and Molecular Biology Letters, 2010, Volume 15, Number 1

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