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The role of P63 in cancer, stem cells and cancer stem cells

1Masaryk Memorial Cancer Institute

2University of Dundee

© 2011 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. (CC BY-NC-ND 3.0)

Citation Information: Cellular and Molecular Biology Letters. Volume 16, Issue 2, Pages 296–327, ISSN (Online) 1689-1392, DOI: 10.2478/s11658-011-0009-9, March 2011

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The transcription factor p63 has important functions in tumorigenesis, epidermal differentiation and stem cell self-renewal. The TP63 gene encodes multiple protein isoforms that have different or even antagonistic roles in these processes. The balance of p63 isoforms, together with the presence or absence of the other p53 family members, p73 and p53, has a striking biological impact. There is increasing evidence that interactions between p53-family members, whether cooperative or antagonistic, are involved in various cell processes. This review summarizes the current understanding of the role of p63 in tumorigenesis, metastasis, cell migration and senescence. In particular, recent data indicate important roles in adult stem cell and cancer stem cell regulation and in the response of cancer cells to therapy.

Keywords: p63; TAp63; ΔNp63; p53 family; Cancer; Stem cells

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Marta Nekulova, Jitka Holcakova, Rudolf Nenutil, Rembert Stratmann, Pavla Bouchalova, Petr Müller, Lucie Mouková, Philip J. Coates, and Borivoj Vojtesek
Virchows Archiv, 2013, Volume 463, Number 3, Page 415
ZhongFa Zhang, Sharmistha Pal, Yingtao Bi, Julia Tchou, and Ramana V Davuluri
Genome Medicine, 2013, Volume 5, Number 4, Page 33
Maisam Makarem, Benjamin T. Spike, Christopher Dravis, Nagarajan Kannan, Geoffrey M. Wahl, and Connie J. Eaves
Journal of Mammary Gland Biology and Neoplasia, 2013, Volume 18, Number 2, Page 209
Qin Huang, Hongyan Wu, Ling Nie, Jiong Shi, Abraham Lebenthal, Jieyu Chen, Qi Sun, Jun Yang, Lily Huang, and Qing Ye
The American Journal of Surgical Pathology, 2013, Volume 37, Number 4, Page 467
Xu-Yong Lin, Yang Liu, Yong Zhang, Juan-Han Yu, and En-Hua Wang
Diagnostic Pathology, 2012, Volume 7, Number 1, Page 118
Varun V Prabhu, Joshua E Allen, Bo Hong, Shengliang Zhang, Hairong Cheng, and Wafik S El-Deiry
Expert Opinion on Therapeutic Targets, 2012, Volume 16, Number 12, Page 1161
G. Vasmatzis, S. H. Johnson, R. A. Knudson, R. P. Ketterling, E. Braggio, R. Fonseca, D. S. Viswanatha, M. E. Law, N. S. Kip, N. Ozsan, S. K. Grebe, L. A. Frederick, B. W. Eckloff, E. A. Thompson, M. E. Kadin, D. Milosevic, J. C. Porcher, Y. W. Asmann, D. I. Smith, I. V. Kovtun, S. M. Ansell, A. Dogan, and A. L. Feldman
Blood, 2012, Volume 120, Number 11, Page 2280
Qin Huang, Jiong Shi, Qi Sun, Xiangshan Fan, Anning Feng, Hongyan Wu, Qiang Zhou, Chenggong Yu, Hiroshi Mashimo, and Gregory Y. Lauwers
Human Pathology, 2012, Volume 43, Number 12, Page 2138
Xiaorong Li, Jing Chen, Yong Yi, Chenghua Li, and Yujun Zhang
Biochemical and Biophysical Research Communications, 2012, Volume 423, Number 2, Page 338
Michael E. Kallen, Melinda E. Sanders, Adriana L. Gonzalez, Jennifer O. Black, Vicki L. Keedy, Kenneth R. Hande, Kelly C. Homlar, Jennifer L. Halpern, Ginger E. Holt, Herbert S. Schwartz, Cheryl M. Coffin, and Justin M. M. Cates
Tumor Biology, 2012, Volume 33, Number 5, Page 1639
Daisuke Nonaka
The American Journal of Surgical Pathology, 2012, Volume 36, Number 6, Page 895
Eviatar Natan and Andreas C. Joerger
Journal of Molecular Biology, 2012, Volume 415, Number 3, Page 503
Michael E. Kallen, Flavia G. Nunes Rosado, Adriana L. Gonzalez, Melinda E. Sanders, and Justin M. M. Cates
Pathology & Oncology Research, 2012, Volume 18, Number 1, Page 97
G Melino
Cell Death and Differentiation, 2011, Volume 18, Number 9, Page 1487

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