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Cellular and Molecular Biology Letters

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Volume 16, Issue 4 (Dec 2011)

ERp57/GRP58: A protein with multiple functions

Carlo Turano / Elisa Gaucci / Caterina Grillo / Silvia Chichiarelli
Published Online: 2011-09-29 | DOI: https://doi.org/10.2478/s11658-011-0022-z


The protein ERp57/GRP58 is a stress-responsive protein and a component of the protein disulfide isomerase family. Its functions in the endoplasmic reticulum are well known, concerning mainly the proper folding and quality control of glycoproteins, and participation in the assembly of the major histocompatibility complex class 1. However, ERp57 is present in many other subcellular locations, where it is involved in a variety of functions, primarily suggested by its participation in complexes with other proteins and even with DNA. While in some instances these roles need to be confirmed by further studies, a great number of observations support the participation of ERp57 in signal transduction from the cell surface, in regulatory processes taking place in the nucleus, and in multimeric protein complexes involved in DNA repair.

Keywords: Protein disulfide isomerases; Calcitriol; STAT3; Cellular stress; Signal transduction; DNA repair

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About the article

Published Online: 2011-09-29

Published in Print: 2011-12-01

Citation Information: Cellular and Molecular Biology Letters, ISSN (Online) 1689-1392, DOI: https://doi.org/10.2478/s11658-011-0022-z.

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