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Catalysis for Sustainable Energy

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One-pot synthesis of new Pyrido [2,3-d] Pyrimidine derivatives under ultrasonic irradiation using organo catalyst 4-Dimethylaminopyridine (DMAP)

Imtiyaz Rasool Parrey
  • Corresponding author
  • Department of Chemistry, Jamia Millia Islamia (Central University),New Delhi-110025 (India)
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Athar Adil Hashmi
  • Corresponding author
  • Department of Chemistry, Jamia Millia Islamia (Central University),New Delhi-110025 (India)
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-12-30 | DOI: https://doi.org/10.1515/cse-2016-0002

Abstract

The one-pot synthesis of pyrido[2,3-d] pyrimidine derivatives has been reported via Knoevenagel-Michal addition pathways using substituted aromatic aldehydes, Cyanoacetamide and 6-aminouracil in N,N-dimethylformamide (DMF) solvent, with 4-dimethylaminopyridine (DMAP) as new organo catalyst catalyst under ultrasonic irradiation. The results showed that a series of aromatic aldehydes were effectively used to prepare the targeted pyrido [2, 3-d] pyrimidine derivatives with good to excellent yields (81-93 %) with no major effect on the yield of product by electron donating/withdrawing substituents. Short reaction time, environment friendly procedure, excellent yields, inexpensive and readily available catalyst are the advantages of this procedure. All synthesized compounds were characterized by IR, 1HNMR, 13CNMR and mass spectral data.

This article offers supplementary material which is provided at the end of the article.

Keywords: Ultrasonic irradiation; 6-Aminouracil; 4-dimethylaminopyridine (DMAP); Substituted aldehydes; N, N-dimethyl formamide

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About the article

Received: 2016-01-24

Accepted: 2016-03-29

Published Online: 2016-12-30


Citation Information: Catalysis for Sustainable Energy, Volume 3, Issue 1, ISSN (Online) 2084-6819, DOI: https://doi.org/10.1515/cse-2016-0002.

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© 2016 Imtiyaz Rasool Parrey, Athar Adil Hashmi . This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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