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Drug Metabolism and Personalized Therapy

Official journal of the European Society of Pharmacogenomics and Personalised Therapy

Editor-in-Chief: Llerena, Adrián

Editorial Board Member: Chen, Bing / Dahl, Marja-Liisa / Devinsky, Ferdinand / Hirata, Rosario / Hubacek, Jaroslav A. / Ingelman-Sundberg, Magnus / Maitland-van der Zee, Anke-Hilse / Manolopoulos, Vangelis G. / Marc, Janja / Melichar, Bohuslav / Meyer, Urs A. / Nair, Sujit / Nofziger, Charity / Peiro, Ana / Sadee, Wolfgang / Salazar, Luis A. / Simmaco, Maurizio / Turpeinen, Miia / Schaik, Ron / Shin, Jae-Gook / Visvikis-Siest, Sophie / Zanger, Ulrich M.

4 Issues per year


CiteScore 2016: 1.40

SCImago Journal Rank (SJR) 2016: 0.413
Source Normalized Impact per Paper (SNIP) 2016: 0.537

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2363-8915
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Volume 26, Issue 2 (Aug 2011)

Issues

Drug interactions in African herbal remedies

Werner Cordier
  • Department of Pharmacology, Faculty of Health Sciences, School of Medicine, University of Pretoria, Pretoria, South Africa
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Vanessa Steenkamp
  • Department of Pharmacology, Faculty of Health Sciences, School of Medicine, University of Pretoria, Pretoria, South Africa
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2011-07-15 | DOI: https://doi.org/10.1515/dmdi.2011.011

Abstract

Herbal usage remains popular as an alternative or complementary form of treatment, especially in Africa. However, the misconception that herbal remedies are safe due to their “natural” origins jeopardizes human safety, as many different interactions can occur with concomitant use with other pharmaceuticals on top of potential inherent toxicity. Cytochrome P450 enzymes are highly polymorphic, and pose a problem for pharmaceutical drug tailoring to meet an individual’s specific metabolic activity. The influence of herbal remedies further complicates this. The plants included in this review have been mainly researched for determining their effect on cytochrome P450 enzymes and P-glycoprotein drug transporters. Usage of herbal remedies, such as Hypoxis hemerocallidea, Sutherlandia frutescens and Harpagophytum procumbensis popular in Africa. The literature suggests that there is a potential for drug-herb interactions, which could occur through alterations in metabolism and transportation of drugs. Research has primarily been conducted in vitro, whereas in vivo data are lacking. Research concerning the effect of African herbals on drug metabolism should also be approached, as specific plants are especially popular in conjunction with certain treatments. Although these interactions can be beneficial, the harm they pose is just as great.

Keywords: African herbals; African potato; cytochrome P450; Devil’s claw; herb-drug interactions; Sutherlandia

About the article

Corresponding author: Vanessa Steenkamp, Department of Pharmacology, Faculty of Health Sciences, School of Medicine, University of Pretoria, P.O. Box X323, Arcadia, 0007, Pretoria, South Africa Phone: +27-12-3192547, Fax: +27-12-3192411


Received: 2011-04-25

Accepted: 2011-06-16

Published Online: 2011-07-15

Published Online: 2011-07-15

Published in Print: 2011-08-01

Published in Print: 2011-07-15


Citation Information: Drug Metabolism and Drug Interactions, ISSN (Online) 2191-0162, ISSN (Print) 0792-5077, DOI: https://doi.org/10.1515/dmdi.2011.011.

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