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Drug Metabolism and Personalized Therapy

Official journal of the European Society of Pharmacogenomics and Personalised Therapy

Editor-in-Chief: Llerena, Adrián

Editorial Board: Benjeddou, Mongi / Chen, Bing / Dahl, Marja-Liisa / Devinsky, Ferdinand / Hirata, Rosario / Hubacek, Jaroslav A. / Ingelman-Sundberg, Magnus / Maitland-van der Zee, Anke-Hilse / Manolopoulos, Vangelis G. / Marc, Janja / Melichar, Bohuslav / Meyer, Urs A. / Nair, Sujit / Nofziger, Charity / Peiro, Ana / Sadee, Wolfgang / Salazar, Luis A. / Simmaco, Maurizio / Turpeinen, Miia / Schaik, Ron / Shin, Jae-Gook / Visvikis-Siest, Sophie / Zanger, Ulrich M.

CiteScore 2018: 1.01

SCImago Journal Rank (SJR) 2018: 0.277
Source Normalized Impact per Paper (SNIP) 2018: 0.446

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Volume 26, Issue 2


Rhabdomyolysis-induced acute renal failure due to itraconazole and simvastatin association

Sébastien Roques / Maria Lytrivi / Daniel Rusu / Jacques Devriendt / David De Bels
Published Online: 2011-04-18 | DOI: https://doi.org/10.1515/dmdi.2011.106


We present the case of an 82-year-old man admitted to our hospital for muscle weakness. He was under simvastatin 20 mg per day and was given pulse itraconazole therapy 8 days before the onset of symptoms for onychomycosis. He developed severe rhabdomyolysis inducing an acute renal failure necessitating renal replacement therapy. He eventually fully recovered. Given the possible concurrent use of simvastatin and itraconazole, awareness of this potential interaction is clinically important.

Keywords: acute renal failure; hepatic metabolism; itraconazole; pharmacological interaction; rhabdomyolysis; simvastatin

About the article

Corresponding author: David De Bels, Intensive Care Unit, Salle 92, Brugmann University Hospital, 4 Place A. Van Gehuchten, 1020 Brussels, Belgium Phone: +32 2 4779293, Fax: +32 2 4779294

Received: 2010-12-14

Accepted: 2011-03-11

Published Online: 2011-04-18

Published Online: 2011-04-18

Published in Print: 2011-08-01

Citation Information: Drug Metabolism and Drug Interactions, Volume 26, Issue 2, Pages 79–80, ISSN (Online) 2191-0162, ISSN (Print) 0792-5077, DOI: https://doi.org/10.1515/dmdi.2011.106.

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